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. 2016 May 13;10:127. doi: 10.3389/fncel.2016.00127

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Copyright © 2016 Zhuo, Peng, Liu, Yan, Xu, Zheng, Wei and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of further introduction of G312A and ΔpCt, either individually or simultaneously, into the WT subunit of G312A-WT on the gating processes induced by 2-APB and extracellular alkalization. (A) Exemplar current-voltage recordings from oocytes expressing G312A-ΔpCt and G312A-G312A/ΔpCt channels in the presence of 100 μM 2-APB. (B) Concentration responses of indicated channels activated by 2-APB. ***p < 0.001 compared with G312A-WT. ^###p < 0.05 compared with G312A-G312A. (C) Exemplar current-voltage recordings from oocytes expressing G312A-ΔpCt and G312A-G312A/ΔpCt channels as pH_o transitions among 6.5, 8.0 and 9.3. (D) Comparative analysis of pH_o-inhibition curves for the indicated channels. ***p < 0.001 compared with G312A-WT. ^###p < 0.05 compared with G312A-G312A.