Table 1.
Anatomical distribution of Aβ deposits in the two cases of iatrogenic Creutzfeldt-Jakob disease (iCJD). Focal Aβ deposits are stratified as mature (classic) plaques and other (immature primitive plaques or compact plaques). Diffuse Aβ deposits include here only subpial deposits. If there was no difference between the two sides (R: right, L: left) they are summarized in one row. Further Aβ deposition indicates lake-like immunoreactivity in the lesion area, deposits in a venous dilatation (temporal in iCJD-1) and amorphous deposits in the dura
| Region/Aβ | iCJD-1 | iCJD-2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CAA | Focal | Diffuse | Further | CAA | Focal | Diffuse | Further | |||
| Mature | Other | Mature | Other | |||||||
| Frontobasal La | − | − | + | − | − | ++ | ++ | ++ | + | − |
| Frontobasal Rb | ++ | +++ | +++ | − | +++ | + | − | + | − | + |
| Middle Fr L | − | + | + | − | − | ++ | ++ | ++ | − | − |
| Middle Fr R | + | − | + | − | − | + | − | + | − | − |
| Middle-Upper Te L | + | + | + | − | − | + | − | ++ | + | − |
| Middle-Upper Te R | + | + | + | − | + | + | − | + | − | − |
| Inferior Pa R-L | − | − | − | − | − | + | + | + | − | − |
| Occ R-L | + | − | − | − | − | + | − | + | − | − |
| Hippocampusc R-L | − | − | − | − | − | + | − | − | − | − |
| Basal GGl R-L | − | − | − | − | − | − | − | − | − | − |
| Thalamus R-L | − | − | − | − | − | − | − | − | − | − |
| Mesencephalon | − | − | − | − | − | − | − | − | − | − |
| Pons | − | − | − | − | − | − | − | − | − | − |
| Medulla oblongata | − | − | − | − | − | − | − | − | − | − |
| Cerebellum | − | − | − | − | − | − | − | − | − | − |
| Dura graft | + | − | − | − | + | + | − | − | − | + |
| Dura hostd | − | − | − | − | − | − | − | − | − | − |
R right, L left, Fr frontal, Te temporal, Pa parietal, Occ occipital, GGl Ganglia, − indicates negative, +, ++, +++ indicates positive (mild, moderate, severe, respectively)
aSite of dural grafting in iCD-2
bSite of dural grafting in iCD-1
cCornu ammonis, subiculum, entorhinal and inferior temporal cortex
dHost dura was examined beside the grafted dura in iCJD-1 and more than 5 cm away from the operation site in iCJD-2