Table 1.

Semi-mechanistic models describing blood count over time

Reference		Drug	Observed variable	Para	Trb	kprol c	Drug effect
Minami (1998)	[14]	Paclitaxel	WBC	4	Lag time	Zero order	E max
Friberg (2000)	[15]	DMDC	ANC	7	9	Zero order	E max
Zamboni (2001)	[16]	Topotecan	ANC	4	1	Zero order	E max
Friberg (2002)	[17]	Docetaxel, etoposide, and paclitaxel	ANC WBC	5	3	First order	Linear
Panetta (2003)	[18]	TMZ	ANC	5	2	First order	E max
Bulitta (2009)	[19]	Paclitaxel paclitaxel EL	ANC	5	1d	Zero order	Linear

WBC white blood cell count, ANC absolute neutrophil count, TMZ temozolomide

^aNumber of parameters estimated in pharmacodynamic model

^bNumber of transit compartments or if lag time is used

^cProliferation rate constant

^dMaturating pool of cells