Figure 8. A simple schematic illustrating the relationship of Sst‐GABA neurons in the NTS‐DMV circuitry that regulates parasympathetic output to the stomach .

Both in the DMV and in the NTS, Sst‐GABA neurons regulate output signalling whose inhibition by α‐MSH or DAMGO results in contrasting effects on motility. This is reminiscent of GABA blockade in both nuclei. In the NTS, inhibition of Sst‐GABA neurons ‘decouples’ inhibitory output (blue neuron) to the DMV that results in suppression of motility. In the DMV, inhibition of Sst‐GABA neurons lead to the release of inhibitory ‘brake’ on excitatory output (orange neuron) to the stomach (i.e. gastric‐antrum), which increases motility. The insert summarizes the major findings of the inter‐relationship between Sst‐GABA neurons and DMV gastric‐antrum projecting neurons. AP, action potential; f, frequency.