Table S1.

Characteristics of risk prediction models in CHB patients

Factors	Risk predictors	Prediction risk score in CHB patients (category)
		GAG		CU	LSM	REACH-B	REACH-B (nomogram)			Lin			Lee	Kim
	No. of model	2		1	1	1	3			3			1	1
CHB, chronic hepatitis B; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; LSM, liver stiffness measure; ALT, alanine aminotransferase; AST, serum aspartate transaminase; AAR, AST/ALT ratio; AFP, alpha-fetoprotein; GGT, gamma-glutamyltransferase; *, HBeAg/HBV DNA level (copies/mL); **, HBeAg/HBV DNA level (copies/mL)/HBV genotype; ***, HBeAg/HBV DNA level (copies/mL); ****, HBeAg/HBV DNA level (copies/mL)/HBsAg(IU/mL)/HBV genotype.
Host factors	Age	Years entered as continuous variable	Years entered as continuous variable	0 (≤50 years)	0 (≤50 years)	0 (30-34 years)	0 (30-34 years)	0 (30-34 years)	0 (30-34 years)	0 (40-44 years)	0 (40-44 years)	0 (40-44 years)	0 (30-34 years)	0 (≤50 years)
				3 (>50 years)	10 (>50 years)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	1 (5-year increments)	0.05306 (>50 years)
	Gender	0 (female)	0 (female)			0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)
		16 (male)	14 (male)			2 (male)	2 (male)	2 (male)	2 (male)	1 (male)	1 (male)	1 (male)	4 (male)	1.106 (male)
	Family history						0 (no)	0 (no)	0 (no)
							2 (yes)	2 (yes)	2 (yes)
Environmental factors	Alcohol						0 (no)	0 (no)	0 (no)
							1 (yes)	2 (yes)	2 (yes)
Virological factors	HBeAg					0 (negative)	0 (negative)	0 [negative/<300 (undetectable)]*	0 [negative/<300 (undetectable)]**	0 (negative/≤10,000)***		0 (negative/≤10,000)***	0 (negative/<104/<100)****
						2 (positive)	3 (positive)	1 (negative/300-9,999)	1 (negative/300-9,999 )	3 (negative/>10,000)		3 (negative/>10,000)	2 (negative/<104/100-999)
	HBV DNA	(copies/mL in log)×3 entered as continuous variable	(copies/mL in log)×3 entered as continuous variable	0 (≤4 log copies/mL)	0 (≤20,000 IU/mL)	0 (<9,999 copies/mL)		3 (negative/10,000-99,999)	3 (negative/10,000-99,999/B or B+C)	6 (positive)		5 (positive)	2 (negative/<104/≥1,000)	0 (≤20,000 IU/mL)
				1 (4-6 log copies/mL)	5 (>20,000 IU/mL)	3 (10,000-99,999 copies/mL)		4 (negative/100,000-999,999)	4 (negative/10,000-99,999/C)				3 (negative/104-106/<100)	0.50969 (>20,000 IU/mL)
				4 (>6 log copies/mL)		5 (100,000-999,999 copies/mL)		5 (negative/1,000,000)	3 (negative/100,000-999,999/B or B+C)				3 (negative/104-106/100-999)
						4 (≥106 copies/mL)		6 (positive)	7 (negative/100,000-999,999/C )				4 (negative/104-106/≥1,000)
	HBV genotype								4 (negative/≥1,000,000/B or B+C )				5 (negative/≥106/any level/B or B+C)
									7 (negative/≥1,000,000/C )				7 (negative/≥106/any level/C)
	Quantitative serum HBsAg levels								6 (positive/B or B+C)				6 (positive/any level/any level/B or B+C)
									6 (positive/C)				7 (positive/any level/any level/C)
	Core promoter mutations	0 (wild-type)
		19 (mutant)
Liver-related seromarkers	Cirrhosis/LSM	0 (no)	0 (no)	0 (no)	0 (≤8.0 kPa)									0 (≤7.7 kPa)
		30 (yes)	33 (yes)	15 (yes)	8 (8.1-12.0 kPa)									0.04858 (>7.7 kPa)
					14 (>12.0 kPa)
	Albumin			0 (>35 g/L)	0 (>35 g/L)						0 (>4.1 g/dL)	0 (>4.1 g/dL)
				20 (≤35 g/L)	1 (≤35 g/L)						4 (≤4.1 g/dL)	3 (≤4.1 g/dL)
	Bilirubin			0 (>18 μmol/L)
				1.5 (≤18 μmol/L)
	ALT					0 (<15 IU/L)	0 (<15 IU/L)	0 (<15 IU/L)	0 (<15 IU/L)	0 (<28 IU/L)	0 (<28 IU/L)	0 (<28 IU/L)	0 (<15 IU/L)
						1 (15-44 IU/L)	1 (15-44 IU/L)	1 (15-44 IU/L)	1 (≥15 IU/L)	2 (≥28 IU/L)	5 (≥28 IU/L)	3 (≥28 IU/L)	1 (15-44 IU/L)
						2 (≥45 IU/L)	3 (≥45 IU/L)	2 (≥45 IU/L)					3 (≥45 IU/L)
	AAR										0 (<1)	0 (<1)
											7 (≥1)	6 (≥1)
	AFP										0 (<5 ng/mL)	0 (<5 ng/mL)
											5 (≥5 ng/mL)	4 (≥5 ng/mL)
	GGT										0 (<41 IU/L)	0 (<41 IU/L)
											4 (≥41 IU/L)	4 (≥41 IU/L)
	Alpha-1 globulin										0 (>0.2 g/dL)	0 (>0.2 g/dL)
											2 (≤0.2 g/dL)	2 (≤0.2 g/dL)
	Sum	−	−	0-43.5	0-30	0-17	0-17	0-20	0-20	0-15	0-33	0-33	0-19	−