. 2016 Apr;28(2):150–160. doi: 10.21147/j.issn.1000-9604.2016.02.02

Table S2.

Characteristics of risk prediction models in cirrhosis, CHC patients and general population

Factors	Risk predictors	Prediction risk score in cirrhosis patients (category)			Prediction risk score in CHC patients (category)
	Risk predictors	ADRESS	AFP-Based Algorithm (no score)		Chang	Chang (SVR)	Michikawa
	No. of model	1	1		1	1	1
CHC, chronic hepatitis C; HCV, hepatitis C virus; CLD, chronic liver disease; BMI, body mass index; DM, diabetes mellitus; Anti-HCV, anti-hepatitis C virus antibody; HBsAg, hepatitis B surface antigen; SVR, sustained virological response; CTP, Child-Turcotte-Pugh; ALT, alanine aminotransferase; AFP, alpha-fetoprotein; AST, serum aspartate transaminase; MET, metabolic equivalent.
Host factors	Age	years×0.0532 entered as continuous variable	√		0 (<60 years)	0 (<60 years)	0 (40-49 years)
					1 (≥60 years)	5 (≥60 years)	2 (50-59 years)
							3 (60-69 years)
	Gender	0 (female)			0 (female)		0 (female)
	Gender	0.5114 (male)			1 (male)		2 (male)
	Race	0 (non-Hispanic white)
	Race	0.2058 (nonwhite or Hispanic)
	BMI						0 (<25 kg/m2)
	BMI						1 (≥25 kg/m2)
	DM	0 (no)
	DM	0.2135 (yes)
Environmental factors	Alcohol						0 (<450 g/week ethanol or past)
							1 (never)
							2 (≥450 g/week ethanol)
Virological factors	HCV genotype				0 (non G1b)		−1 (ribonucleic acid-negative)
					1 (G1b)		0 (G2)
							2 (G1)
	SVR				0 (yes)
	SVR				2 (no)
Liver-related seromarkers	Cirrhosis	0 (autoimmune)			0 (fibrosis stage: 0-2)	0 (fibrosis stage: 0-2)
		0.3509 (alcohol/metabolic)			2 (fibrosis stage: 3-4)	6 (fibrosis stage: 3-4)
		1.246 (viral)
	Severity of CTP	CTP score×0.0532 entered as continuous variable
	ALT		√				0 (<30 IU/L)
							3 (30-69 IU/L)
							5 (≥70 IU/L)
	AFP		√		0 (<20 ng/mL)	0 (<20 ng/mL)
	AFP				1 (≥20 ng/mL)	4 (≥20 ng/mL)
	Platelet		√		0(≥150×109/L)	0(≥150×109/L)
	Platelet				1(<150×109/L)	4(<150×109/L)
	Sum	−	−		0-9	0-19	−1-15
Factors	Risk predictors	Prediction risk score in general population (category)
	Risk predictors	Michikawa	Wen
	No. of model	1	9
Host factors	Age	0 (40-49 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)
		2 (50-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)
		3 (60-69 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)
	Gender	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)			0 (female)
	Gender	2 (male)	2 (male)	2 (male)	1 (male)	1 (male)	1 (male)	1 (male)			1 (male)
	BMI	0 (<25 kg/m2)
	BMI	1 (≥25 kg/m2)
	Physical activity		0 (<3.75 MET-h)		0 (<7.5 MET-h)	0 (<7.5 MET-h)	0 (<7.5 MET-h)
	Physical activity		−1 (≥3.75 MET-h)		−1 (≥7.5 MET-h)	−1 (≥7.5 MET-h)	−1 (≥7.5 MET-h)
	DM	0 (no)	0 (no)		0 (no)	0 (no)	0 (no)		0 (no)	0 (no)	0 (no)
	DM	1 (yes)	2 (yes)		1 (yes)	1 (yes)	1 (yes)		1 (yes)	1 (yes)	1 (yes)
Environmental factors	Smoking		0 (<1 pack-years)		0 (<1 pack-years)	0 (<10 pack-years)	0 (<10 pack-years)		0 (<10 pack-years)	0 (<10 pack-years)	0 (<10 pack-years)
	Smoking		1 (≥1 pack-years)		1 (≥1 pack-years)	1 (≥10 pack-years)	1 (≥10 pack-years)		1 (≥10 pack-years)	1 (≥10 pack-years)	1 (≥10 pack-years)
	Alcohol	0 (<450 g/week ethanol)	0 (none or occasional)		0 (none or occasional)	0 (none or occasional)	0 (none or occasional)		0 (none or occasional)	0 (none or occasional)	0 (none or occasional)
		1 (never or past)	1 (regular)		1 (regular)	1 (regular)	1 (regular)		1 (regular)	1 (regular)	1 (regular)
		2 (≥450 g/week ethanol))
	Coffee	0 (almost never to <1 cup/d)
	Coffee	−1 (≥1 cup/d)
Virological factors	Anti-HCV	0 (negative)									0 (negative)
	Anti-HCV	6 (positive)									5 (positive)
	HBsAg	0 (negative)				0 (negative)				0 (negative)	0 (negative)
	HBsAg	4 (positive)				4 (positive)				4 (positive)	6 (positive)
Liver-related seromarkers	ALT			0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)		0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)
	ALT			2 (≥25 IU/L)	1 (≥25 IU/L)	1 (≥25 IU/L)		3 (≥25 IU/L)	1 (≥25 IU/L)	2 (≥25 IU/L)	2 (≥25 IU/L)
	AFP					0 (<2.5 ng/mL)				0 (<2.5 ng/mL)	0 (<2.5 ng/mL)
						1 (2.5-4.9 ng/mL)				2 (2.5-4.9 ng/mL)	2 (2.5-4.9 ng/mL)
						4 (5.0-9.9 ng/mL)				5 (5.0-9.9 ng/mL)	5 (5.0-9.9 ng/mL)
						8 (≥10.0 ng/mL)				9 (≥10.0 ng/mL)	9 (≥10.0 ng/mL)
	AST			0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)		0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)
				5 (25-39 IU/L)	4 (25-39 IU/L)	4 (25-39 IU/L)		4 (25-39 IU/L)	5 (25-39 IU/L)	4 (25-39 IU/L)	4 (25-39 IU/L)
				9 (40-59 IU/L)	9 (40-59 IU/L)	7 (≥40 IU/L)		8 (40-59 IU/L)	8 (40-59 IU/L)	6 (40-59 IU/L)	6 (40-59 IU/L)
				13 (≥60 IU/L)	12 (≥60 IU/L)			11 (≥60 IU/L)	11 (≥60 IU/L)	8 (≥60 IU/L)	7 (≥60 IU/L)
	Sum	−1-19	−1-12	0-23	−1-23	−1-30	−1-10	0-21	0-21	0-32	0-39
Factors	Risk predictors	Prediction risk score in general population (category)
	Risk predictors	Hung
	No. of model	4
Host factors	Age	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)
		3 (40-49 years)	3 (40-49 years)	3 (40-49 years)	3 (40-49 years)
		5 (50-59 years)	5 (50-59 years)	5 (50-59 years)	5 (50-59 years)
		7 (≥60 years)	7 (≥60 years)	7 (≥60 years)	7 (≥60 years)
	Gender	0 (female)	0 (female)	0 (female)	0 (female)
	Gender	3 (male)	3 (male)	3 (male)	3 (male)
	First-degree family history of HCC		0 (no)	0 (no)	0 (no)
	First-degree family history of HCC		2 (yes)	2 (yes)	2 (yes)
Environmental factors	Smoking		0 (<18 pack-years)	0 (<18 pack-years)	0 (<18 pack-years)
Environmental factors	Smoking		1 (≥18 pack-years)	1 (≥18 pack-years)	1 (≥18 pack-years)
Virological factors	HBsAg or Anti-HCV				0 (negative)
	HBsAg or Anti-HCV				9 (positive)
	HBsAg			0 (negative)
	HBsAg			7 (positive)
Liver-related seromarkers	ALT	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)
	ALT	3 (≥25 IU/L)	3 (≥25 IU/L)	3 (≥25 IU/L)	3 (≥25 IU/L)
	Previous CLD		0 (no)	0 (no)	0 (no)
	Previous CLD		3 (yes)	3 (yes)	3 (yes)
	Sum	0-13	0-19	0-26	0-28