Table S3.

 

Factors	Risk predictors	Prediction risk score in general population (category)
		Michikawa	Wen
	No. of model	1	9
Host factors	Age	0 (40-49 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)	0 (20-39 years)
		2 (50-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)	2 (40-59 years)
		3 (60-69 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)	6 (≥60 years)
	Gender	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)	0 (female)			0 (female)
		2 (male)	2 (male)	2 (male)	1 (male)	1 (male)	1 (male)	1 (male)			1 (male)
	BMI	0 (<25 kg/m2)
		1 (≥25 kg/m2)
	Physical activity		0 (<3.75 MET-h)		0 (<7.5 MET-h)	0 (<7.5 MET-h)	0 (<7.5 MET-h)
			−1 (≥3.75 MET-h)		−1 (≥7.5 MET-h)	−1 (≥7.5 MET-h)	−1 (≥7.5 MET-h)
	DM	0 (no)	0 (no)		0 (no)	0 (no)	0 (no)		0 (no)	0 (no)	0 (no)
		1 (yes)	2 (yes)		1 (yes)	1 (yes)	1 (yes)		1 (yes)	1 (yes)	1 (yes)
Environmental factors	Smoking		0 (<1 pack-years)		0 (<1 pack-years)	0 (<10 pack-years)	0 (<10 pack-years)		0 (<10 pack-years)	0 (<10 pack-years)	0 (<10 pack-years)
			1 (≥1 pack-years)		1 (≥1 pack-years)	1 (≥10 pack-years)	1 (≥10 pack-years)		1 (≥10 pack-years)	1 (≥10 pack-years)	1 (≥10 pack-years)
	Alcohol	0 (<450 g/week ethanol)	0 (none or occasional)		0 (none or occasional)	0 (none or occasional)	0 (none or occasional)		0 (none or occasional)	0 (none or occasional)	0 (none or occasional)
		1 (never or past)	1 (regular)		1 (regular)	1 (regular)	1 (regular)		1 (regular)	1 (regular)	1 (regular)
		2 (≥450 g/week ethanol))
	Coffee	0 (almost never to <1 cup/d)
		−1 (≥1 cup/d)
Virological factors	Anti-HCV	0 (negative)									0 (negative)
		6 (positive)									5 (positive)
	HBsAg	0 (negative)				0 (negative)				0 (negative)	0 (negative)
		4 (positive)				4 (positive)				4 (positive)	6 (positive)
Liver-related seromarkers	ALT			0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)		0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)
				2 (≥25 IU/L)	1 (≥25 IU/L)	1 (≥25 IU/L)		3 (≥25 IU/L)	1 (≥25 IU/L)	2 (≥25 IU/L)	2 (≥25 IU/L)
	AFP					0 (<2.5 ng/mL)				0 (<2.5 ng/mL)	0 (<2.5 ng/mL)
						1 (2.5-4.9 ng/mL)				2 (2.5-4.9 ng/mL)	2 (2.5-4.9 ng/mL)
						4 (5.0-9.9 ng/mL)				5 (5.0-9.9 ng/mL)	5 (5.0-9.9 ng/mL)
						8 (≥10.0 ng/mL)				9 (≥10.0 ng/mL)	9 (≥10.0 ng/mL)
	AST			0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)		0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)	0 (<25 IU/L)
				5 (25-39 IU/L)	4 (25-39 IU/L)	4 (25-39 IU/L)		4 (25-39 IU/L)	5 (25-39 IU/L)	4 (25-39 IU/L)	4 (25-39 IU/L)
				9 (40-59 IU/L)	9 (40-59 IU/L)	7 (≥40 IU/L)		8 (40-59 IU/L)	8 (40-59 IU/L)	6 (40-59 IU/L)	6 (40-59 IU/L)
				13 (≥60 IU/L)	12 (≥60 IU/L)			11 (≥60 IU/L)	11 (≥60 IU/L)	8 (≥60 IU/L)	7 (≥60 IU/L)
	Sum	−1-19	−1-12	0-23	−1-23	−1-30	−1-10	0-21	0-21	0-32	0-39