Table 4.
Comparisons of pharmacokinetic parameters of SCT400 and rituximab at 375 mg/m2
| Parameters | SCT400 (n=9) | Rituximab (n=14) | ||
| 1st | 4th | 1st | 4th | |
| T1/2, terminal half-life; Cmax, maximum concentration; AUC0→168, area under the concentration-time curve from time zero to 168 h after the end the infusion; AUC0→∞, area under the concentration-time curve from time zero to infinity; CL, clearance. | ||||
| T1/2 (h) | 122.5±47.0 | 197.0±75.0 | 76.3±31.1 | 205.8±95.0 |
| Cmax (μg/mL) | 200.6±20.0 | 339.1±71.0 | 205.6±59.9 | 464.7.0±119.0 |
| AUC0→168 (μg·h/mL) | 15,197±4,182 | − | 16,320 | − |
| AUC0→∞ (μg·h/mL) | − | 86,502±39,602 | − | 86,125 |
| CL (mL/h) | 33.7±32.8 | 12.5±17.0 | 38.2±18.2 | 9.2±3.3 |