Table 1.

The most abundant bioactive factors determined by Ray Biotech protein assay analysis in the secretome of lytic HCMV-infected cells.

				Cell types
Classification	Symbol	Gene annotation	Biological function	NHDF1	HUVEC2	LEC3
Cytochine/chemochine	CXCL1; GROα	Chemokine (C-X-C motif) ligand 1	Chemoattractant for neutrophils	•	•	•
	CXCL5; ENA-78	Chemokine (C-X-C motif) ligand 5	Recruitment and activation of leukocytes	•		•
	CXCL6; GCP-2	Chemokine (C-X-C motif) ligand 6	Chemoattractant for neutrophilic granulocytes		•
	CXCL9; MIG	Chemokine (C-X-C motif) ligand 9	Leukocyte trafficking			•
	CXCL10; IP-10	Chemokine (C-X-C motif) ligand 10	Stimulation of monocytes, natural killer, and T-cell migration	•	•
	CXCL11; I-TAC	Chemokine (C-X-C motif) ligand 11	Chemoattractant	•	•	•
	CXCL16	Chemokine (C-X-C motif) ligand 16	Recruitment of leukocytes	•	•
	CCL1; I-309	Chemokine (C-C motif) ligand 1	Leukocyte trafficking			•
	CCL3; MlP-1α	Chemokine (C-C motif) ligand 3	Inflammatory responses	•	•
	CCL4; MlP-1β	Chemokine (C-C motif) ligand 4	Chemokinetic and inflammatory functions	•	•	•
	CCL5; RANTES	Chemokine (C-C motif) ligand 5	Chemoattractant for blood monocytes, memory T helper cells and eosinophils	•	•
	CCL7; MCP-3	Chemokine (C-C motif) ligand 7	Chemoattractant for macrophages	•	•	•
	CCL8; MCP-2	Chemokine (C-C motif) ligand 8	Leukocyte trafficking		•	•
	CCL15; MIP-1δ	Chemokine (C-C motif) ligand 15	T-cells and monocyte chemoattractant			•
	CCL20; MIP-3α	Chemokine (C-C motif) ligand 20	Leukocyte trafficking	•	•	•
	CCL23; MPIF-1	Chemokine (C-C motif) ligand 23	Chemotactic activity on resting T lymphocytes and monocytes		•
	IL-1α	Interleukin-1α	Role in immune responses and inflammatory processes			•
	IL-3	Interleukin-3	Role in cell growth, differentiation, and apoptosis			•
	IL-5	Interleukin-5	Growth and differentiation factor for B cells and eosinophils	•		•
	IL-6	Interleukin-6	Anti-inflammatory cytokine	•	•	•
	IL-8	Interleukin-8	Leukocyte trafficking	•	•
	IL-10	Interleukin-10	Anti-inflammatory cytokine			•
	IL-13	Interleukin-13	Anti-inflammatory cytokine			•
	IL-15	Interleukin-15	T and natural killer cells activation and proliferation			•
	LTA; TNF-β	Lymphotoxin A	Proinflammatory cytokine			•
	TNF-α	Tumor necrosis factor alpha	Proinflammatory cytokine		•	•
	Osteoprotegerin	PG/TNFRSF11B	Lymph-node organogenesis and vascular calcification	•	•
Growth factor	GM-CSF	Granulocyte-Macrophage Colony-Stimulating-Factor	Bone and cartilagine development	•	•	•
	bFGF	Fibroblast Growth Factor 2 (basic)	Mitogenic and angiogenic activities			•
	TGF-β1	Transforming growth factor beta 1	Cell growth, proliferation, differentiation, adhesion, and migration	•		•
	HGF	Hepatocyte growth factor	Angiogenesis	•
Receptor	ICAM-1	Intercellular adhesion molecule 1	Cell adhesion for endothelial and immune system cells	•	•	•
	TNF-RI	Tumor necrosis factor receptor 1	Regulator of inflammation	•		•
	TNF-RII	Tumor necrosis factor receptor 2	Regulator of inflammation	•
ECM	MMP-1	Matrix metallopeptidase 1	Disruption of extracellular matrix	•		•
	TIMP-1	TIMP metallopeptidase inhibitor 1	Inhibitor of the matrix metalloproteinases	•
	TIMP-2	TIMP metallopeptidase inhibitor 2	Inhibitor of the matrix metalloproteinases	•
	TIMP-4	TIMP metallopeptidase inhibitor 4	Inhibitor of the matrix metalloproteinases	•
Enzyme	ANG	Angiogenin, ribonuclease, RNase A family, 5	Angiogenesis	•