Table 2.
Main bioactive proteins assessed in the HCMV secretome of latently infected CD34+ cells.
| Classification | Symbol | Gene annotation | Biological function |
|---|---|---|---|
| Cytochine/chemochine | XCL1; LTN | Chemokine (C motif) ligand 1 | Leukocyte trafficking |
| CXCL9; MIG | Chemokine (C-X-C motif) ligand 9 | Leukocyte trafficking | |
| CXCL12; SDF1 | Chemokine (C-X-C motif) ligand 12 | Leukocyte trafficking | |
| CXCL13; BLC | Chemokine (C-X-C motif) ligand 13 | B lymphocyte chemoattractant | |
| CCL1; I-309 | Chemokine (C-C motif) ligand 1 | Leukocyte trafficking | |
| CCL2; MCP-1 | Chemokine (C-C motif) ligand 2 | Leukocyte trafficking | |
| CCL8; MCP-2 | Chemokine (C-C motif) ligand 8 | Leukocyte trafficking | |
| CCL13; MCP-4 | Chemokine (C-C motif) ligand 13 | Leukocyte trafficking | |
| CCL15; MIP-1δ | Chemokine (C-C motif) ligand 15 | T-cells and monocyte chemoattractant | |
| CCL17; TARC | Chemokine (C-C motif) ligand 17 | T cells chemotaxis and trafficking | |
| CCL20; MIP-3α | Chemokine (C-C motif) ligand 20 | Leukocyte trafficking | |
| CCL27; CTACK | Chemokine (C-C motif) ligand 27 | T-cell-mediated inflammation, T lymphocyte chemoattractant | |
| IL-8 | Interleukin-8 | Leukocyte trafficking | |
| IL-10; CSIF | Interleukin-10 | Anti-inflammatory cytokine | |
| IL-13 | Interleukin-13 | Anty-inflammatory cytokine | |
| IL-15 | Interleukin-15 | T and natural killer cells activation and proliferation | |
| LEP | Leptin | Angiogenesis and wound healing | |
| LTA; TNF-β | Lymphotoxin A | Proinflammatory cytokine | |
| TNF-α | Tumor necrosis factor alpha | Proinflammatory cytokine | |
| Growth factor | BMP-4 | Bone morphogenetic protein 4 | Bone and cartilagine development |
| BMP-6 | Bone morphogenetic protein 6 | Bone and cartilagine growth | |
| CSF-1; M-CSF | Colony stimulating factor 1 | Monocytes proliferation, differentiation, and survival | |
| IGF-1; MGF | Insulin-like growth factor 1 | Cell growth and development | |
| IGFBP3; IBP3 | Insulin-like growth factor binding protein 3 | Cell growth and development | |
| NT-3; NTF3 | Neurotrophin-3 | Neurogenesis | |
| TGF-β1 | Transforming growth factor beta 1 | Cell growth, proliferation, differentiation, adhesion and migration | |
| TGF-β3 | Transforming growth factor beta 3 | Cell adhesion, proliferation, differentiation | |
| Receptor | ICAM-1 | Intercellular adhesion molecule 1 | Cell adhesion for endothelial and immune system cells |
| Enzyme | ANG | Angiogenin, ribonuclease, RNase A family | Angiogenesis |