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. 2016 May 15;8(5):416–426. doi: 10.4251/wjgo.v8.i5.416

Table 1.

Association of microRNA expression and clinical parameters

microRNA Clinical parameter Change of expression Ref.
miR-17-5p Association with rectal cancer survival No further explanation Slattery et al[59]
miR-20a/20b-5p
miR-21-3p/5p
miR-25-3p
miR-29a/29c-3p
miR-31-5p Association with advanced tumor stage Increased expression level in advanced tumor stage Slattery et al[59]
miR-135b Correlation with disease-free and cancer-specific survival Patients with a high expression level of miR-135b had a better disease-free and cancer-specific survival Gaedcke et al[38]
miR-135b Correlation with Duke stage IV Upregulated with the highest fold-change (17.7-fold) among 9 upregulated miRNAs Xu et al[58]
miR-141-3p Association with rectal cancer survival No further explanation Slattery et al[59]
miR-145 Correlation with Duke stage II, III, IV Downregulated with a -18.15, -18.9, -23.8-fold change in stage II, III and IV CRC respectively Xu et al[58]
miR-145-5p Correlation with advanced tumor stage Increased expression level in advanced tumor stage Slattery et al[59]
miR-155 Correlation with nodal stage and Duke stage Discrimination of nodal positive from negative cases as well as Duke A/B stages from Duke C/D stages Yang et al[61]
miR-200b-3p Association with advanced tumor stage and survival Decreased expression level in advanced tumor stage Slattery et al[59]
miR-215 Association with advanced tumor stage and survival Decreased expression level in advanced tumor stage Slattery et al[59]
miR-335-5p Association between any miRNA expression and survival The expression of miR-335-5p is associated with a better survival Slattery et al[59]
miR-374a Correlation with metastasis stage Decreased expression of miR-374a in tumor of patients without metastasis Xu et al[58]
miR-425-5p Association with rectal cancer survival No further explanation Slattery et al[59]
miR-451a Association with advanced tumor stage Decreased expression level in advanced tumor stage Slattery et al[59]

CRC: Colorectal carcinoma.