Figure 6. Conditional knocked out Notch1 in newborn neurons of the hippocampus impaired spatial learning and memory with the Morris water maze (MWM) test.

(a) The 5 days learning trial of Notch1 conditional knockout (cKO), Notch intracellular domain (NICD) conditional overexpression (cOE), and control mice. At day 4, Notch1 cKO mice showed a need for a significantly longer time to find the hidden platform compared to NICD cOE and control group mice. (b) Probe test result of Notch1 cKO, NICD cOE and control mice. Notch1 cKO mice spent less time in the target quadrant than the NICD cOE and control group mice. (n = 10 for Notch1 cKO and NICD cOE mice, n = 13 for control mice, *p < 0.05).