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Five levels of ASMR
| Level of ASMR | Criteria |
|---|---|
| I | Major innovation: innovative product with substantial therapeutic benefit |
| II | Important improvement in terms of therapeutic efficacy and/or reducing side effects |
| III | Moderate improvement in terms of therapeutic efficacy and/or utility |
| IV | Minor improvement in terms of therapeutic efficacy and/or reducing side effects |
| V | No improvement over existing options but still can be recommended for reimbursement (e.g., generic drugs and me-too drugs) |
