Table IV.

Relative Therapeutic Index (ITR) driving pricing and reimbursement

ITR		Level of reimbursement	Price
−1	Inferiority compared to the relevant comparator	None	–
	Non-relevant comparator
	Unacceptable methodology
	Lack of proof
0	Non-inferiority compared to the relevant comparator	Same as that of the comparator	Article R 163-5 (a price that will enable expenditure savings versus the comparator)
1	Minor improvement compared to the relevant comparator	Same as that of the comparator	Framework agreement with CEPS
	Improvement of conditions of use with impact on care and non-inferiority compared to the comparator
2	Moderate improvement compared to the relevant comparator	Same as that of the comparator	Framework agreement with CEPS
≥3	Major improvement compared to the relevant comparator	Same as or more than that of the comparator	Framework agreement with CEPS