Table VI.
Impact of attributes in mean price change: repositionings
| USA | Europe | ||||||
|---|---|---|---|---|---|---|---|
| Description of attribute | Description of mean price change* (%) | Description of attribute | Description of mean price change* (%) | ||||
| Attribute | Category | Mean (SD)/freq (%) of attribute | Mean (SD)/correlation | P | Mean (SD)/freq (%) of attribute | Mean (SD)/correlation | P |
| Disease-related | |||||||
| ICD-10 chapter change | Yes No |
17 (74%) 6 (26%) |
0.48 (0.80) 0.67 (0.52) |
0.58 | 41 (77%) 12 (23%) |
0.45 (0.55) 0.75 (0.45) |
0.1 |
| Prevalence change | 78 (3,224) | −0.25 | 0.39** | −34 (2,013) | 0.13 | 0.54** | |
| DALY change | −30,39,602 (49,67,661) | −0.35 | 0.01** | −31,90,669 (53,42,501) | 0.55 | 0.08** | |
| Demographic group change | Adults No change Pediatrics |
3 (13%) 18 (78%) 2 (9%) |
0.23 (0.22) 0.56 (0.76) 1.00 (–) |
0.67 | 8 (15%) 40 (75.5%) 5 (9.5%) |
−0.29 (0.51) 0.68 (0.47) 0.00 (0.00) |
0.0006 |
| Number of alternative treatments change | −10 (17) | −0.14 | 0.63** | −10.5 (17) | −0.05 | 0.04** | |
| Drug-related | |||||||
| Frequency of use change | Increase No change Decrease |
2 (10%) 16 (69%) 5 (23%) |
(–) 0.62 (0.47) 0.45 (1.30) |
0.91 | 5 (9.5%) 39 (73.5%) 9 (17%) |
−0.07 (–) 0.65 (0.52) 0.11 (0.31) |
0.30 |
| Change in administration setting | Ambulatory No change Hospital |
– 22 (96%) 1 (4%) |
– 0.55 (0.70) – |
– | – 51 (96%) 2 (4%) |
(–) 0.56 (0.53) (–) |
– |
| Addressing unmet needs | Yes No |
8 (35%) 15 (65%) |
0.62 (0.47) 0.49 (0.85) |
0.69 | 26 (49%) 27 (51%) |
0.66 (0.48) 0.42 (0.59) |
0.20 |
| Improved patient convenience | Yes No |
1 (4%) 22 (96%) |
– 0.55 (0.70) |
– | – 53 (100%) |
– 0.56 (0.53) |
– |
| Repurposing-related | |||||||
| Repositioning approach | Serendipity Hypothesis driven |
9 (39%) 14 (61%) |
0.72 (0.77) 0.39 (0.65) |
0.31 | 17 (32%) 36 (68%) |
0.76 (0.62) 0.50 (0.50) |
0.23 |
| Repositioning target | On-target Off-target |
20 (87%) 3 (13%) |
0.55 (0.73) 0.50 (0.71) |
0.91 | 45 (85%) 8 (15%) |
0.54 (0.54) 0.73 (0.53) |
0.47 |
| Regulatory-related | |||||||
| Patent expiry | Before After |
16 (70%) 7 (30%) |
0.61 (0.65) 0.10 (1.27) |
0.31 | 47 (89%) 6 (11%) |
0.56 (0.53) (–) |
– |
| Brand name | Same Different |
14 (61%) 9 (39%) |
0.56 (0.50) 0.52 (1.04) |
0.89 | 34 (64%) 19 (36%) |
0.75 (0.44) 0.24 (0.53) |
0.004 |
| Company | Same Different |
17 (74%) 6 (26%) |
0.62 (0.67) 0.20 (0.92) |
0.32 | 45 (85%) 8 (15%) |
0.56 (0.50) 0.59 (0.82) |
0.90 |
| Designation change | Orphan to orphan Non-orphan Orphan No change |
3 (13%) 2 (9%) 5 (22%) 13 (56%) |
0.54 (0.65) 0.02 (0.03) 0.77 (0.47) 0.57 (0.87) |
<0.001 | 6 (11%) – 15 (28%) 32 (60%) |
0.08 (–) – 0.63 (0.50) 0.53 (0.58) |
0.81 |
*
Mean price change expressed as a quantitative variable. E.g. a value of 0.50 should be interpreted as an increase in price by 50%.
**
P value derived from linear regression with the baseline variable as a covariate.