Table 2.
Effect of Direct-Acting Antiviral Agents on the Levels of Commonly Used Immunosuppressants
| Direct-Acting Antiviral Agent(s) | Cyclosporine | Tacrolimus | Mycophenolate |
|---|---|---|---|
| Daclatasvir | No change in level | No change in level | No change in level |
| Ledipasvir | No change in level | No change in level | No change in level |
| Simeprevir | Contraindicated | No change in level | No change in level |
| Sofosbuvir | No change in level | No change in level | No change in level |
| 3D | Increased levels | Increased levels | Increased levels |
3D, combination of ombitasvir, paritaprevir with ritonavir, and dasabuvir.