Table.
Cases of RTX and Colitis
| Case | Age, Sex | Indication(s) | Treatment(s)/Outcome |
|---|---|---|---|
| 1 | 67, M | Relapse of follicular lymphoma | Subtotal colectomy; died of recurrent bacterial pneumonia 4 months after surgery1 |
| 2 | 26, F | Non-Hodgkin lymphoma treatment | Colectomy2 |
| 3 | 45, F | Clinical trial for Grave’s disease | Mesalamine-induced remission3 |
| 4 | 58, M | Long-standing ulcerative colitis unresponsive to corticosteroids, immunosuppressants, and biologics | 5-ASA, corticosteroids, and ciprofloxacin; patient suffered from 10-15 loose stools/day and was considered for proctocolectomy4 |
| 5 | 4, M | Refractory minimal-change disease nephrotic syndrome | Corticosteroid-induced remission. Eventually, the nephrotic syndrome relapsed5 |
| 6 | 34, unknown | Corticosteroid-, cyclophosphamide-, and methotrexate-resistant bullous systemic lupus erythematous | Episode of acute appendicitis with appendectomy. Later developed ulcerative colitis. When RTX was withdrawn, symptoms resolved6 |
| 7 | 38, F | Refractory seronegative rheumatoid arthritis | Corticosteroid- and 5-ASA–induced remission7 |
| 8 | 62, F | Disseminated marginal zone B-cell lymphoma | Initially patient underwent subtotal colectomy and on subsequent RTX re-exposure patient experienced active proctitis requiring completion proctectomya |
5-ASA, 5-aminosalicylic acid; F, female; M, male; RTX, rituximab.
a
The current case.