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. 2016 May 13;6:25974. doi: 10.1038/srep25974

Figure 5. Enhanced SI in Nav1.6 correlates with reduced resurgent currents.

Figure 5

(A) Representative resurgent current traces recorded by the depicted protocol of Nav1.6 (left panel), the mutation Nav1.6/V966C (middle panel) and the mutation Nav1.6/N1455A (right panel) under conditions that favor resurgent currents. The maximal resurgent current obtained by a repolarizing pulse to −10 mV is colored green. Cells expressing Nav1.6 WT and the Nav1.6/V966C mutant show robust resurgent currents (B) in 90 to 100% of cells (black bars) (C) whereas the N1455A mutant was not able to produce any resurgent currents. Significant differences between Nav1.6 WT and Nav1.6/N1455A are marked with blue*, between Nav1.6 WT and Nav1.6/V966C with red* and between Nav1.6/N1455A and Nav1.6/V966C with #p < 0.05.