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. 2016 May 13;6:25974. doi: 10.1038/srep25974

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Copyright © 2016, Macmillan Publishers Limited

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(A) 500 μM LCM shift voltage-dependence of steady-state SI of Nav1.7 WT to more hyperpolarized potentials (ΔV_1/2 = 36.3 mV, V_1/2 = −63.5 ± 2.1 mV for Nav1.7 control (filled black squares, n = 10) and −99.8 ± 1.2 mV for Nav1.7 500 μM LCM (filled green squares, n = 6)). The data were recorded with the protocol depicted in Fig. 3 (inset). (B) Representative resurgent currents traces of Nav1.7 recorded at the indicated test pulses before (black) and after application of 500μM LCM (green) via perfusion to the same cell. (C) Resurgent current amplitude (black squares) decreased after the application of 500 μM LCM (filled green squares, n = 6). Transient peak current was reduced by LCM, therefore resurgent currents are displayed as percentage of transient peak currents of each trace and plotted as a function of voltage. *p < 0.05 and **p < 0.005 (paired t-test).