Table 1. S. japonicum EV proteins are homologous to exosomal proteins in other species.

Description of the identified proteins in S. japonicum EVs	Homologs of exosomal proteins in other species			E value$	Identities (%)
	Plasma	Cells	Parasites
Actin	√50	√51	√27	0	91
26 S proteasome regulatory subunit T3		√52		0	89
Proteasome (Prosome, macropain) 26 S subunit, ATPase 2			√27	0	88
Proteasome (Prosome, macropain) 26 S subunit, ATPase 3		√52		0	83
Eukaryotic translation elongation factor 1 alpha 2		√51	√27	0	81
CDC42 protein	√50,53			2.00E-109	78
26 S proteasome regulatory subunit N11		√54		3.00E-179	78
Glyceraldehyde 3-phosphate dehydrogenase	√50	√51	√19	0	75
Heat shock protein 70	√53	√51	√14,26	0	72
Glucose-6-phosphate isomerase	√53			0	70
Proteasome subunit beta type 5		√52	√26	7.00E-102	70
Heat shock protein 90	√53	√52	√14	0	68
Phosphoglycerate kinase		√54		0	68
Rab-protein 11		√54	√14,19	2.00E-89	68
Proteasome (Prosome, macropain) subunit alpha type 4		√51	√27	E-118	67
Glutamine synthetase	√53			0	66
26 S proteasome non-ATPase regulatory subunit 7				6.00E-126	66
Rab-protein 10	√53	√54	√19	E-89	65
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide		√51,54		6.00E-112	64
Lactate dehydrogenase		√54		2.00E-144	61
Proteasome subunit beta type 6			√26	2.00E-87	61
20 S proteasome subunit alpha 7		√52	√27	3.00E-105	60
Proteasome subunit beta type 7		√54	√26	9.00E-117	60

^$The protein sequences in S. japonicum were analyzed with the homologs in Mus musculus by BLASTP program. Blast E value and identities was calculated.