Table 1. Selected compounds from the FBSS and SBVS and their corresponding IC50 and MICs.
| Initial hits | MIC μg/ml | ||||||
|---|---|---|---|---|---|---|---|
| IC50 [mM] | S. aureus | S. epidermidis | E. coli | ||||
| Name | PhoRS | PhoRE | HK853 | WalK | DSM 20231 | DSM 20044 | CFT 073 |
| F1 | n.d. | 2 | n.d. | >2 | 25 | 4 | >500 |
| F2 | n.d. | 0.3 | n.d. | >2 | 31 | >500 | >500 |
| S1 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
| S2 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
| S3 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
| S4 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
| S5 | ≈1 | ≈1 | >5 | >1 | >500 | 500# | >500 |
| S6 | 1.14 | 0.37 | >5 | >1 | >500 | 500# | 500# |
| S7 | <5* | >5 | >5 | >5 | >500 | >500 | >500 |
| S8 | <5* | >5 | >5 | >5 | >500 | >500 | >500 |
| S9 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
| S10 | >5 | >5 | >5 | >5 | >500 | >500 | >500 |
*% Inhibition at 5 mM ≥ 70%, i.e. IC50 < 5 mM.
#MBC > 500 μg/ml.