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. 2016 May 11;7:11445. doi: 10.1038/ncomms11445

Figure 3. SIRT1 levels are abnormally reduced in the cerebellum of MJD Tg mouse model and CR re-establishes normal SIRT1 cerebellar levels.

Figure 3

(a) SIRT1 is compromised in the cerebellum of Tg MJD mice. A significant decrease of 58.4±8.3% in mRNA levels of SIRT1 was detected. These results were supported by western blotting in (b). Data represent mean±s.e.m.; NS P>0.05 and *P<0.05 compared with Tg-AL. (a,b) WT n=5; Tg-AL n=5; Tg-CR n=4. SIRT1.1 (SIRT1 isoform 1) and SIRT1.2 (SIRT1 isoform 2). See also Supplementary Fig. 2.