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. 2016 May 12;6:25626. doi: 10.1038/srep25626

Figure 2. Neuroprotective activity of Fraction 0–4 in brain slice assays for neurodegeneration induced by APP and tau.

Figure 2

Left, example photomicrographs showing cortical neurons transfected with YFP only (“Con”) or with YFP plus a human WT amyloid precursor protein (“APP”) or a human tau4R0N (“tau4R”) expression construct as indicated. Overt neurodegeneration and cell loss driven by either APP or tau4R by 3 days after transfection (compare middle to left panels) could be rescued by treatment with 30 μM Fraction 0–4 (right panels). Right, Concentration-response relations for Fraction 0–4 in the brain slice APP and tau4R assays as indicated. Averages of 3 and 4 independent runs are shown for APP and tau4R, respectively, with the negative-control conditions (treated with DMSO only) set to 100%. For both graphs, dark green bars denote statistically significant differences with respect to the respective APP or tau4R negative-controls by ANOVA followed by Dunnett’s post hoc comparison test at the 0.05 confidence level.