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. Author manuscript; available in PMC: 2017 Apr 21.
Published in final edited form as: Cell Chem Biol. 2016 Apr 21;23(4):443–452. doi: 10.1016/j.chembiol.2016.03.010

Figure 3. GNF2-biotin interacts specifically with dengue virions.

Figure 3

(A) Structure of GNF2- biotin and schematic of experiment to detect its interaction with dengue virions. (B) DENV2 NGC virions but not vesicular stomatitis virions are captured on streptavidin-derivatized beads in the presence of GNF2-biotin. (C) Affinity capture of dengue virions is more efficient at 37 degrees C than at 4 degrees C and is correlated with the sensitivity of the virus to GNF-2, as evidenced by little or no affinity capture of DENV3 TDH3 virions. Representative data for two or more independent experiments are shown.