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. Author manuscript; available in PMC: 2016 May 13.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Apr 2;35(5):1218–1225. doi: 10.1161/ATVBAHA.115.305476

Figure 4. Loss of IL-21R signaling results in impaired perfusion recovery following HLI.

Figure 4

(A) Laser Doppler imaging showed significantly impaired perfusion recovery in Il21r−/− mice in C57BL/6 background compared to gender-matched and age matched wide type (WT) littermates at day14 and 21 after HLI (n=9–12 per group). (B) WT C57BL/6 mice that received 6 intraperitoneal (i.p) doses of IL-21R-Fc fusion protein (200 mg/mouse at days 0, 1, 3, 7, 9 and 11 after HLI) showed significantly lower perfusion recovery when compared with vehicle treated mice (control) at days 14 and 21 after HLI (n = 11–12/group). (C) At day 21 after HLI, ischemic gastrocnemius muscle from Il21r−/− mice showed significant lower capillary density than WT littermates (n = 9/group). Average capillaries per muscle fiber: 1.6 ± 0.1 vs 1.1 ± 0.1, p<0.001. Data = mean ± SEM. WT, wild type. KO, Il21r knockout.