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. Author manuscript; available in PMC: 2016 May 13.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Apr 2;35(5):1218–1225. doi: 10.1161/ATVBAHA.115.305476

Figure 5. Il21r knockout mice had decreased STAT3 phosphorylation and BCL-2/BAX ratio after HLI.

Figure 5

(A) Consistent with in vitro data shown in Figure 3, Il21r−/− mice showed less STAT3 phosphorylation in ischemic gastrocnemius muscle, but did not show any difference of STAT1, AKT or ERK1/2 phosphorylation 1 day after HLI when compared to ischemic gastrocnemius muscle from the WT mice. (B) In gastrocnemius muscle at day 7 after HLI, l21r KO had a decreased BCL-2/BAX ratio. N=4–5/group, Data = mean ± SEM. WT, wild type. KO, Il21r knockout.