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. Author manuscript; available in PMC: 2016 May 13.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Apr 2;35(5):1218–1225. doi: 10.1161/ATVBAHA.115.305476

Figure 6. A schematic of proposed IL-21/IL-21R signal in endothelial cells.

Figure 6

(A) From Castermans et al32, under normoxic conditions with the presence of basic fibroblastic growth factor (b-FGF), IL-21 activates the STAT1 pathway, which results in angiostatic effects. (B) From our study, under HSS conditions, IL-21R is upregulated; IL-21 promotes STAT3 signaling, leading to increased BCL-2/BAX ratio, and results in increased endothelial cell survival and angiogenesis.