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Plk1 PBD IC50 values measured in an ELISA competition assay.a
| No. | Ring Size | IC50 (μM) |
|---|---|---|
| 1 | – | 29 |
| 2 | – | 0.011 |
| 3a | 18 | 0.14 |
| 3b | 20 | 0.015 |
| 3c | 22 | 0.014 |
| 3d | 24 | 0.11 |
| 4a | 15 | 1.8 |
| 4b | 18 | 0.83 |
| 4c | 20 | 0.14 |
| 4d | 22 | 0.24 |
| 4e | 24 | 13 |
| 5a | 14 | 19 |
| 5b | 16 | 9.4 |
| 5c | 18 | 29 |
| 5d | 20 | 25 |
| 5e | 22 | 99 |
| 5f | 24 | 200 |
Values were obtained in an ELISA-based assay that measured the ability of peptides to compete with an immobilized pT78 peptide for binding to HEK 293A cell lysate-derived GFP-HA-fused Plk1.
