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PA binding is required for nuclear localization of IP6K1. IP6K1-KO cells were transfected with plasmids harboring GFP-tagged WT or mutant IP6K1. Intracellular localization of IP6K1 (upper panel) was determined by fluorescence microscopy. The number of cells showing each phenotype (lower panel) was determined in three independent experiments (n > 150). Values are mean ± S.E.
