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. 2016 Mar 7;291(20):10437–10444. doi: 10.1074/jbc.M116.714816

FIGURE 7.

FIGURE 7.

Model of regulation of mIno1 transcription by IP6K1. PA binding facilitates localization of IP6K1 to the nucleus, where it associates with chromatin and synthesizes IP7/PP-IP4. IP7/PP-IP4 represses mIno1 expression by promoting methylation of mIno1 DNA and/or inhibiting the transcription apparatus.