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. 2016 Mar 24;291(20):10625–10634. doi: 10.1074/jbc.M116.713768

FIGURE 3.

FIGURE 3.

Hepatic overexpression of miR-291b-3p induces lipid accumulation in the liver. 6–8-week-old male C57BL/6J mice on a chow diet were injected with the recombinant adenovirus expressing a miR-291b-3p mimic (Ad-291m) or Ad-Con and sacrificed 7 days after injection. A, hepatic levels of miR-291b-3p. B, biochemical analysis of AST and ALT in mice treated with the adenovirus vectors. C, quantification of IL6 and TNFα expression in the livers. D and E, body weight, liver weight, and liver weight-to-body weight ratio. F, H&E and Oil Red O staining of liver frozen sections. G, hepatic triglyceride content. H, Western blots of hepatic SREBP1 and FAS protein levels. **, p < 0.01; ***, p < 0.001. n = 6.