Table 2. Multivariable analysis for survival data, including stromal CXCL14 expression.
| Number (CXCL14 data) |
N=498 (394) |
|||||
|---|---|---|---|---|---|---|
|
Breast cancer-specific survival |
Recurrence-free survival |
|||||
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
|
Age (years) | ||||||
| ⩽50 | 1 | 1 | ||||
| >50 | 0.762 | 0.411–1.412 | 0.388 | 0.731 | 0.451–1.184 | 0.203 |
|
Tumour size (mm) | ||||||
| ⩽20 | 1 | 1 | ||||
| >20 | 1.619 | 0.974–2.691 | 0.063 | 1.224 | 0.823–1.821 | 0.318 |
|
NHG | ||||||
| I | 1 | 1 | ||||
| II | 2.289 | 0.843–6.214 | 0.104 | 2.948 | 1.457–5.966 | 0.003* |
| III | 5.645 | 2.139–14.900 | <0.0001* | 5.427 | 2.680–10.990 | <0.0001* |
|
Node status | ||||||
| Negative | 1 | 1 | ||||
| Positive | 4.155 | 2.402–7.186 | <0.0001* | 2.482 | 1.657–3.717 | <0.0001* |
|
ER status | ||||||
| Negative | 1 | 1 | ||||
| Positive | 0.664 | 0.320–1.376 | 0.271 | 1.005 | 0.546–1.851 | 0.987 |
|
HER2 status | ||||||
| 0 | 1 | 1 | ||||
| 1 | 1.393 | 0.782–2.479 | 0.260 | 1.461 | 0.933–2.289 | 0.098 |
| 2 | 1.005 | 0.422–2.398 | 0.990 | 1.206 | 0.623–2.335 | 0.578 |
| 3 | 0.774 | 0.336–1.787 | 0.549 | 0.706 | 0.347–1.439 | 0.338 |
|
Stromal CXCL14 | ||||||
| Negative | 1 | 1 | ||||
| Positive | 1.877 | 1.123–3.138 | 0.016* | 1.602 | 1.050–2.443 | 0.029* |
Abbreviations: CI=confidence interval; ER=oestrogen receptor; HR=hazard ratio; NHG=Nottingham histological grade; PR=progesterone receptor; TNBC=triple-negative breast cancers.
Cox regression analysis using stromal CXCL14 as categorical variable in multivariable analysis.
*P=<0.05.