Table 1. Clinicopathological variables as predictors of disease-specific survival in LN+ NSCLC patients in the overall cohort and stratified into the SCC and ADC subgroups (univariate analyses, log-rank test, N=172, 91 and 68, respectively).
|
All |
SCC |
ADC |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N(%) | 5Y | M | HR (95% CI) | P | N(%) | 5Y | M | HR (95%CI) | P | N(%) | 5Y | M | HR (95%CI) | P | |
| Age | 0.591 | 0.384 | 0.008 | ||||||||||||
| ⩽65 | 80 (47) | 29 | 24 | 1 | 43 (47) | 45 | 33 | 1 | 34 (50) | 5 | 23 | 1 | |||
| >65 | 92 (53) | 34 | 27 | 0.9 (0.62–1.32) | 48 (53) | 33 | 25 | 1.26 (0.74–2.16) | 34 (50) | 40 | 47 | 0.46 (0.25–0.83) | |||
| Gender | 0.280 | 0.967 | 0.122 | ||||||||||||
| Female | 46 (27) | 34 | 44 | 1 | 15 (16) | 43 | 28 | 1 | 25 (37) | 32 | 44 | 1 | |||
| Male | 126 (73) | 30 | 24 | 1.27 (0.84–1.92) | 76 (84) | 39 | 25 | 1.02 (0.5–2.07) | 43 (63) | 17 | 24 | 1.62 (0.9–2.94) | |||
| ECOG | 0.854 | 0.519 | 0.206 | ||||||||||||
| 0 | 97 (56) | 31 | 27 | 1 | 45 (49) | 33 | 21 | 1 | 43 (63) | 29 | 43 | 1 | |||
| 1 | 61 (35) | 34 | 23 | 1.12 (0.74–1.68) | 38 (42) | 44 | 33 | 0.94 (0.54–1.63) | 20 (29) | 14 | 15 | 1.62 (0.82–3.22) | |||
| 2 | 14 (8) | 38 | 25 | 0.97 (0.43–2.18) | 8 (9) | 57 | NA | 0.44 (0.16–1.24) | 5 (7) | 25 | 17 | 2.02 (0.45–9.13) | |||
| Smoking | 0.094 | 0.252 | 0.266 | ||||||||||||
| Never | 5 (3) | 0 | 14 | 1 | 3 (3) | 0 | 12 | 1 | 2 (3) | 0 | 15 | 1 | |||
| Previous | 103 (60) | 31 | 29 | 0.36 (0.07–1.86) | 53 (58) | 39 | 29 | 0.33 (0.03–3.75) | 43 (63) | 18 | 25 | 0.4 (0.04–3.93) | |||
| Present | 64 (37) | 35 | 25 | 0.34 (0.06–1.8) | 35 (38) | 43 | 28 | 0.31 (0.03–3.59) | 23 (34) | 32 | 36 | 0.32 (0.03–3.17) | |||
| Weight loss | 0.477 | 0.593 | 0.410 | ||||||||||||
| <10% | 154 (90) | 32 | 25 | 1 | 81 (89) | 40 | 28 | 1 | 61 (90) | 26 | 27 | 1 | |||
| ⩾10% | 18 (10) | 16 | 15 | 1.25 (0.63–2.48) | 10 (11) | 44 | 11 | 1.28 (0.46–3.56) | 7 (10) | 0 | 15 | 1.43 (0.53–3.84) | |||
| Surgical procedure | 0.326 | 0.970 | 0.116 | ||||||||||||
| Wedge/Lobectomy | 89 (52) | 32 | 41 | 1 | 38 (42) | 41 | 28 | 1 | 45 (66) | 26 | 43 | 1 | |||
| Pulmonectomy | 83 (48) | 31 | 20 | 1.21 (0.82–1.78) | 53 (58) | 38 | 21 | 1.01 (0.59–1.73) | 23 (34) | 20 | 15 | 1.62 (0.83–3.19) | |||
| Margins | 0.195 | 0.364 | 0.626 | ||||||||||||
| Free | 148 (86) | 34 | 27 | 1 | 77 (85) | 42 | 28 | 1 | 59 (87) | 25 | 27 | 1 | |||
| Not free | 24 (14) | 16 | 23 | 1.41 (0.78–2.53) | 14 (15) | 26 | 25 | 1.37 (0.64–2.94) | 9 (13) | 0 | 23 | 1.24 (0.49–3.15) | |||
| T stage | 0.009 | 0.026 | 0.018 | ||||||||||||
| IA | 12 (7) | 89 | 127 | 1 | 6 (7) | 100 | 127 | 1 | 6 (9) | 83 | NA | 1 | |||
| IB | 21 (12) | 25 | 28 | 6.43 (3–13.76) | 9 (10) | 44 | 33 | 4.95 (1.64–14.87) | 9 (13) | 0 | 24 | 9.99 (3.26–30.62) | |||
| IIA | 69 (40) | 34 | 25 | 6.58 (3.56–12.15) | 36 (40) | 42 | 29 | 6.22 (2.58–15) | 30 (44) | 23 | 24 | 8.14 (3.49–18.98) | |||
| IIB | 29 (17) | 21 | 20 | 7.99 (3.84–16.62) | 18 (20) | 21 | 16 | 9.5 (3.4–26.52) | 10 (15) | 22 | 47 | 5.28 (1.88–14.8) | |||
| III | 37 (22) | 18 | 16 | 9.1 (4.45–18.61) | 19 (21) | 33 | 17 | 7.06 (2.55–19.56) | 13 (19) | 0 | 12 | 14.51 (4.71–44.69) | |||
| IV | 4 (2) | 0 | 15 | 15.61 (2.52–96.52) | 3 (3) | 0 | 10 | 27.6 (1.37–556) | |||||||
| N stage | 0.035 | 0.010 | 0.542 | ||||||||||||
| 1 | 118 (69) | 36 | 35 | 1 | 73 (80) | 45 | 35 | 1 | 39 (57) | 25 | 30 | 1 | |||
| 2 | 54 (31) | 21 | 19 | 1.52 (0.99–2.34) | 18 (20) | 18 | 13 | 2.14 (1.02–4.51) | 29 (43) | 23 | 24 | 1.2 (0.65–2.22) | |||
| P stage | 0.016 | 0.035 | 0.416 | ||||||||||||
| IIA | 72 (42) | 44 | 43 | 1 | 43 (47) | 55 | 71 | 1 | 26 (38) | 28 | 30 | 1 | |||
| IIB | 16 (9) | 32 | 28 | 1.27 (0.66–2.46) | 12 (13) | 31 | 19 | 1.59 (0.7–3.61) | 4 (6) | 38 | 47 | 0.67 (0.21–2.09) | |||
| IIIA | 84 (49) | 19 | 17 | 1.79 (1.19–2.68) | 36 (40) | 23 | 15 | 2.09 (1.15–3.83) | 38 (56) | 11 | 24 | 1.37 (0.74–2.53) | |||
| Histology | 0.869 | ||||||||||||||
| SCC | 91 (53) | 39 | 25 | 1 | |||||||||||
| ADC | 68 (40) | 23 | 25 | 1.1 (0.74–1.65) | |||||||||||
| NOS | 13 (8) | 17 | 19 | 1.12 (0.52–2.41) | |||||||||||
| Differentiation | 0.417 | 0.399 | 0.851 | ||||||||||||
| Poor | 94 (55) | 25 | 24 | 1 | 41 (45) | 32 | 20 | 1 | 40 (59) | 19 | 27 | 1 | |||
| Moderate | 68 (40) | 38 | 33 | 0.84 (0.57–1.25) | 45 (49) | 46 | 35 | 0.75 (0.43–1.31) | 23 (34) | 24 | 21 | 0.96 (0.51–1.81) | |||
| Well | 10 (6) | 43 | 41 | 0.56 (0.25–1.26) | 5 (5) | 38 | 41 | 0.47 (0.15–1.43) | 5 (7) | 60 | NA | 0.66 (0.2–2.22) | |||
| Vascular infiltration | 0.018 | 0.007 | 0.808 | ||||||||||||
| No | 128 (74) | 37 | 30 | 1 | 68 (75) | 46 | 35 | 1 | 54 (79) | 22 | 24 | 1 | |||
| Yes | 43 (25) | 18 | 18 | 1.65 (1.02–2.68) | 23 (25) | 17 | 18 | 2.16 (1.05–4.44) | 13 (19) | 30 | 36 | 0.91 (0.43–1.92) | |||
| Missing | 1 (1) | 1 (1) | |||||||||||||
Abbreviations: ADC=adenocarcinom; CI=confidence interval; ECOG=Eastern Cooperative Oncology Group; HR=hazard ratio; LN, lymph node; NOS=not otherwise specified; NSCLC= non-small cell lung cancer; SCC=squamous cell carcinoma.