Table 1. Distributions of patient characteristics and toxicity.
| RAPPER (N=533) | RADIOGEN (N=597) | GenePARE (N=290) | CCI (N=150) | P-valuea | |
|---|---|---|---|---|---|
|
Age | |||||
| Mean (s.d.) | 67.2 (5.7) | 71.0 (6.5) | 64.0 (7.5) | 66.7 (7.4) | P<0.00005 |
|
Diabetes | |||||
| Yes, n (%) | 39 (7.3) | 144 (24.1) | 16 (5.5) | 24 (16.0) | P<0.00005 |
| No, n (%) | 493 (92.5) | 453 (75.9) | 274 (94.5) | 122 (81.3) | |
| Missing, n (%) | 1 (0.2) | 0 | 0 | 4 (2.7) | |
|
Prior TURP | |||||
| Yes, n (%) | 56 (10.5) | 45 (7.5) | 6 (2.1) | 6 (4.0) | P=0.0002 |
| No, n (%) | 472 ((88.6) | 552 (92.5) | 284 (97.9) | 144 (96.0) | |
| Missing, n (%) | 5 (0.9) | 0 | 0 | 0 | |
|
BED | |||||
| Mean (s.d.) | 120.5 (6.2) | 120.5 (5.6) | 191.9 (22.4) | 125.5 (6.2) | P<0.00005 |
|
STAT 2 years | |||||
| Mean (s.d.) | −0.01 (0.5) | 0.02 (0.8) | 0.12 (0.7) | −0.01 (0.7) | 0.06 |
|
Decreased stream | |||||
| Grade 0, n (%) | 483 (90.6) | 472 (79.1) | 189 (65.2) | NA | P<0.00005 |
| Grade ⩾1, n (%) | 29 (5.5) | 6 (1.0) | 66 (22.7) | NA | |
| Missing, n (%) | 21 (3.9) | 119 (19.9) | 35 (12.1) | NA | |
|
Urine frequency | |||||
| Grade 0, n (%) | 482 (90.5) | 423 (70.9) | 179 (61.7) | 120 (80) | P<0.00005 |
| Grade ⩾1, n (%) | 45 (8.4) | 54 (9.0) | 76 (26.2) | 30 (20) | |
| Missing, n (%) | 6 (1.1) | 120 (20.1) | 35 (12.1) | 0 | |
|
Rectal bleeding | |||||
| Grade 0, n (%) | 446 (83.7) | 522 (87.4) | 208 (71.7) | 110 (73.3) | |
| Grade ⩾1, n (%) | 81 (15.2) | 74 (12.4) | 82 (28.3) | 40 (26.7) | P<0.00005 |
| Missing, n (%) | 6 (1.1) | 1 (0.2) | 0 | 0 | |
Abbreviations: BED=biologically effective dose; NA=not available; STAT=Standardised Total Average Toxicity; TURP=transurethral resection of the prostate.
a
P-value for test of heterogeneity across cohorts.