Table 3. Polygenic risk score analysis results.

	RAPPER		RADIOGEN		GenePARE		CCI		Meta-analysis
	β (95% CI)	Pa	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P	Q, P-hetb
STAT score
Non-weighted risk score	0.003 (−0.006, 0.01)	0.49	0.003 (−0.008, 0.01)	0.61	−0.01 (−0.03, 0.01)	0.15	−0.01 (−0.04, 0.01)	0.25	0.00002 (−0.01, 0.01)	0.99	3.88, 0.28
Weighted risk score	0.04 (−0.02, 0.10)	0.19	0.03 (−0.05, 0.10)	0.44	−0.06 (−0.17, 0.05)	0.28	−0.09 (−0.26, 0.08)	0.29	0.01 (−0.03, 0.06)	0.49	4.15, 0.25
Decreased stream
Non-weighted risk score	0.01 (−0.06, 0.08)	0.78	0001 (−0.001, 0.003)	0.36	0.004 (−0.06, 0.06)	0.91	NA	NA	0.001 (−0.001, 0.003)	0.35	0.08, 0.96
Weighted risk score	0.34 (−0.15, 0.83)	0.17	0.01 (−0.01, 0.02)	0.36	0.04 (−0.35, 0.43)	0.86	NA	NA	0.01 (−0.01, 0.02)	0.33	1.84, 0.40
Urine frequency
Non-weighted risk score	−0.004 (−0.06, 0.06)	0.90	−0.001 (−0.01, 0.004)	0.66	−0.04 (−0.10, 0.02)	0.18	−0.03 (−0.12, 0.05)	0.45	−0.002 (−0.007, 0.004)	0.54	2.19, 0.53
Weighted risk score	−0.003 (−0.40, 0.40)	0.99	−0.01 (−0.05, 0.02)	0.50	−0.31 (−0.72, 0.08)	0.12	0.04 (−0.56, 0.62)	0.89	−0.01 (−0.05, 0.02)	0.42	2.18, 0.54
Rectal bleeding
Non-weighted risk score	0.04 (−0.009, 0.08)	0.11	−0.002 (−0.01, 0.003)	0.47	−0.02 (−0.08, 0.04)	0.48	−0.0003 (−0.07, 0.07)	0.99	−0.002 (−0.01, 0.003)	0.55	3.22, 0.36
Weighted risk score	0.28 (−0.03, 0.59)	0.08	−0.01 (−0.04, 0.03)	0.78	−0.06 (−0.45, 0.32)	0.75	−0.05 (−0.57, 0.47)	0.86	−0.002 (−0.04, 0.03)	0.90	3.32, 0.34

Abbreviations: CI=confidence interval; NA=not available; STAT=Standardised Total Average Toxicity.

^aP-value corresponding to β-estimate.

^bP-value for test of heterogeneity between studies.