Skip to main content
. 2016 May 13;6:25663. doi: 10.1038/srep25663

Figure 3. Effects of GW2580 treatment on CSF1R signalling in the spinal cord of SOD1G93A mice.

Figure 3

(a–e) Assessment of the mRNA levels of CSF1R transcription factors (a) PU.1, (b) RUNX1 and (c) IRF8 and cell cycle regulators (d) cyclin D2 and (e) D1 in the ventral lumbar spinal cord of SOD1G93A mice. (f) Graph showing the reduction of PU.1+ cells in the ventral horn of spinal cords after GW2580 treatment in 16 weeks old SOD1G93A mice. (g–i) Representative immunohistochemical images showing PU.1+ cells in the ventral horns of L4-L5 segments of WT (g), SOD1G93A control (h) and GW2580-treated SOD1G93A mice (i). G-I Scale bars 200 μm. *p < 0.05 compared to SOD1G93A, #p < 0.05 compared to WT. (n = 3 WT; n = 4 for SOD1G93A control and SOD1G93A treated with GW2580 per time point). Error bars indicate SEM.