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. 2016 May 13;6:25828. doi: 10.1038/srep25828

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Copyright © 2016, Macmillan Publishers Limited

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(A–E) UCSC browser tracks of selected RNA-seq mRNA-reads on purified myelin. Displayed are two myelin-related genes (Mbp, Fth1), one microglial marker (Itgam), one neuronal marker (Kcn4a) and one astrocytic marker (Itga7). Note that mature myelin-related mRNAs were detected. Also see Fig S1C-K. (F) Box-Whisker plots showing transcript read count of all mRNAs identified in myelin purified from male c57Bl6/N mice (age 6 months) compared to total cerebellum, cortex, heart, kidney, liver, and lung. The three biological replicates display similar transcript distribution (R1-R3) and selected myelin-related mRNAs (highlighted) are enriched in myelin compared to the other samples. (G) Heat map showing the abundance of selected myelin-related transcripts in myelin (age 6 months), cerebellum, cortex, heart, kidney, liver, and lung. Note that mRNAs encoding enzymes related to myelin lipids are also enriched in myelin.