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. 2016 May 12;8:54. doi: 10.1186/s13148-016-0219-0

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© Cao-Lei et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — NF-κB signaling pathway with genes associated with objective PNMS. Among the 20 genes selected from NF-κB signaling pathway, DDR1, FLT1, IGF1R, IL1R2, LCK, LTA, MAP4K4, NFKBIA, PIK3CD, TGFBR2, TNFAIP3, and ZAP70 were greater methylated; BCL10, LTBR, MAP3K14, PIK3R2, PRKCZ, TLR6 and TRAF5 were lesser methylated; TNFRSF1B was either greater or lesser methylated depending on the different CpG sites. The gene family A20 (TNFAIP3), growth factor receptor (DDR1, FLT1, IGF1R, and TGFBR2), IkB (NFKBIA), LCK, LTA, and ZAP70 are highlighted in red. The gene family BCL10, LTBR, MEKK3/NIK (MAP3K14), PRKCZ, TRAF2/3/5, and TRAF5/6 are highlighted in green. The gene family IL-1R/TLR (IL1R2 and TLR6), NIK (MAP3K14 and MAP4K4), P13K (PIK3CD and PIK3R2), and TNFR (TNFRSF1B) are highlighted in orange.