Table 2.
Gene | CpG site | DNA methylation | IFN-γ outcome | Mediation effect | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R 2 | Storm32 | R 2 | DNA methylation | Storm32 | |||||||||||||
Effect (a) | SE | p val. | Effect (b) | SE | p val. | Effect (c') | SE | p val. | Effect (a*b) | Boot SE | Boot LLCI | Boot ULCI | Standardized effect | ||||
DDR1 | cg11975790 | 0.1813 | 0.0527 | 0.0201 | 0.0135 | 0.1749 | −0.4065 | 0.1856 | 0.0364 | 0.0474 | 0.0230 | 0.0478 | −0.0214 | 0.0116 | −0.0537 | −0.0045 | −0.170991 |
FLT1 | cg24850711 | 0.2527 | 0.0606 | 0.0187 | 0.0029 | 0.1142 | −0.3210 | 0.2065 | 0.1306 | 0.0454 | 0.0249 | 0.0782 | −0.0195 | 0.0129 | −0.0540 | −0.0010 | −0.155283 |
IGF1R | cg13297560 | 0.1322 | 0.0388 | 0.0178 | 0.0375 | 0.1376 | −0.3883 | 0.2139 | 0.0795 | 0.0410 | 0.0228 | 0.0822 | −0.0151 | 0.0113 | −0.0475 | −0.0007 | −0.120139 |
IL1R2 | cg12910851 | 0.1628 | 0.0353 | 0.0144 | 0.0199 | 0.2001 | −0.6216 | 0.2560 | 0.0214 | 0.0479 | 0.0224 | 0.0406 | −0.0219 | 0.0151 | −0.0659 | −0.0031 | −0.174821 |
LCK | cg17078393 | 0.2561 | 0.0659 | 0.0202 | 0.0027 | 0.1783 | −0.4104 | 0.1846 | 0.0339 | 0.0530 | 0.0241 | 0.0353 | −0.0271 | 0.0139 | −0.0640 | −0.0055 | −0.21591 |
cg05350315 | 0.1949 | 0.0711 | 0.0260 | 0.0101 | 0.1651 | −0.3033 | 0.1447 | 0.0447 | 0.0475 | 0.0233 | 0.0503 | −0.0216 | 0.0145 | −0.0629 | −0.0019 | −0.172012 | |
cg11683242 | 0.1681 | 0.0443 | 0.0177 | 0.0178 | 0.2545 | −0.5858 | 0.2007 | 0.0066 | 0.0519 | 0.0217 | 0.0231 | −0.0259 | 0.0126 | −0.0599 | −0.0073 | −0.206796 | |
cg14781242 | 0.2081 | 0.0505 | 0.0177 | 0.0076 | 0.1625 | −0.4395 | 0.2124 | 0.0472 | 0.0482 | 0.0235 | 0.0495 | −0.0222 | 0.0109 | −0.0519 | −0.0063 | −0.177247 | |
LTA | cg16280132 | 0.3331 | 0.0652 | 0.0166 | 0.0004 | 0.1463 | −0.4366 | 0.2291 | 0.0663 | 0.0544 | 0.0259 | 0.0440 | −0.0285 | 0.0152 | −0.0654 | −0.0047 | −0.227195 |
cg09736959 | 0.2952 | 0.0758 | 0.0210 | 0.0011 | 0.1433 | −0.3391 | 0.1809 | 0.0706 | 0.0517 | 0.0252 | 0.0494 | −0.0257 | 0.0150 | −0.0628 | −0.0014 | −0.20498 | |
cg24216966 | 0.2611 | 0.0886 | 0.0268 | 0.0024 | 0.1401 | −0.2620 | 0.1423 | 0.0755 | 0.0492 | 0.0247 | 0.0555 | −0.0232 | 0.0144 | −0.0628 | −0.0022 | −0.185282 | |
cg01157951 | 0.2634 | 0.0663 | 0.0199 | 0.0023 | 0.1334 | −0.3402 | 0.1922 | 0.0869 | 0.0485 | 0.0248 | 0.0600 | −0.0225 | 0.0140 | −0.0592 | −0.0010 | −0.179876 | |
cg21999229 | 0.2593 | 0.1120 | 0.0340 | 0.0025 | 0.1287 | −0.1940 | 0.1129 | 0.0961 | 0.0477 | 0.0248 | 0.0643 | −0.0217 | 0.0142 | −0.0592 | −0.0002 | −0.17327 | |
cg14597739 | 0.2618 | 0.1198 | 0.0361 | 0.0023 | 0.1504 | −0.2043 | 0.1049 | 0.0608 | 0.0504 | 0.0246 | 0.0487 | −0.0245 | 0.0156 | −0.0674 | −0.0021 | −0.195257 | |
cg16219283 | 0.2575 | 0.1038 | 0.0316 | 0.0026 | 0.1430 | −0.2250 | 0.1202 | 0.0710 | 0.0493 | 0.0246 | 0.0540 | −0.0234 | 0.0151 | −0.0641 | −0.0010 | −0.186303 | |
cg13815684 | 0.2571 | 0.0877 | 0.0268 | 0.0026 | 0.1569 | −0.2838 | 0.1410 | 0.0531 | 0.0509 | 0.0244 | 0.0456 | −0.0249 | 0.0141 | −0.0635 | −0.0038 | −0.198557 | |
cg10476003 | 0.2229 | 0.0794 | 0.0266 | 0.0055 | 0.1749 | −0.3071 | 0.1402 | 0.0364 | 0.0504 | 0.0236 | 0.0410 | −0.0244 | 0.0138 | −0.0656 | −0.0048 | −0.194562 | |
cg09621572 | 0.2220 | 0.1022 | 0.0343 | 0.0056 | 0.1447 | −0.2091 | 0.1107 | 0.0686 | 0.0473 | 0.0240 | 0.0578 | −0.0214 | 0.0141 | −0.0609 | −0.0024 | −0.170417 | |
cg17169196 | 0.2233 | 0.0894 | 0.0299 | 0.0055 | 0.1638 | −0.2615 | 0.1255 | 0.0459 | 0.0493 | 0.0237 | 0.0464 | −0.0234 | 0.0138 | −0.0624 | −0.0042 | −0.186458 | |
cg02402436 | 0.2261 | 0.0932 | 0.0310 | 0.0052 | 0.1323 | −0.2173 | 0.1236 | 0.0890 | 0.0462 | 0.0242 | 0.0661 | −0.0203 | 0.0129 | −0.0574 | −0.0018 | −0.161559 | |
cg14441276 | 0.2038 | 0.0741 | 0.0263 | 0.0084 | 0.1409 | −0.2678 | 0.1448 | 0.0742 | 0.0458 | 0.0238 | 0.0634 | −0.0199 | 0.0136 | −0.0591 | −0.0010 | −0.158425 | |
cg11586857 | 0.1575 | 0.0561 | 0.0233 | 0.0222 | 0.1857 | −0.3647 | 0.1590 | 0.0290 | 0.0464 | 0.0225 | 0.0477 | −0.0205 | 0.0123 | −0.0566 | −0.0033 | −0.163339 | |
cg14437551 | 0.1758 | 0.0986 | 0.0383 | 0.0151 | 0.1758 | −0.2304 | 0.0961 | 0.0230 | 0.0487 | 0.0226 | 0.0393 | −0.0227 | 0.0140 | −0.0635 | −0.0035 | −0.181167 | |
LTBR | cg23079808 | 0.1487 | −0.0474 | 0.0204 | 0.0267 | 0.2281 | 0.4754 | 0.1772 | 0.0118 | 0.0485 | 0.0218 | 0.0337 | −0.0225 | 0.0123 | −0.0521 | −0.0046 | −0.179865 |
MAP3K14 | cg16826777 | 0.1665 | −0.0516 | 0.0207 | 0.0184 | 0.2136 | 0.4488 | 0.1759 | 0.0161 | 0.0491 | 0.0222 | 0.0349 | −0.0231 | 0.0123 | −0.0568 | −0.0055 | −0.184658 |
NFKBIA | cg00689225 | 0.2086 | 0.0668 | 0.0234 | 0.0075 | 0.2304 | −0.4173 | 0.1544 | 0.0112 | 0.0538 | 0.0226 | 0.0236 | −0.0279 | 0.0127 | −0.0630 | −0.0095 | −0.222303 |
cg16518861 | 0.1288 | 0.0439 | 0.0205 | 0.0403 | 0.2475 | −0.4968 | 0.1740 | 0.0077 | 0.0478 | 0.0213 | 0.0322 | −0.0218 | 0.0127 | −0.0579 | −0.0046 | −0.173912 | |
PIK3CD | cg01320698 | 0.3012 | 0.0487 | 0.0133 | 0.0009 | 0.2948 | −0.8481 | 0.2591 | 0.0027 | 0.0673 | 0.0230 | 0.0065 | −0.0413 | 0.0172 | −0.0857 | −0.0155 | −0.329546 |
cg07499142 | 0.1747 | 0.0599 | 0.0234 | 0.0155 | 0.1688 | −0.3416 | 0.1603 | 0.0413 | 0.0464 | 0.0230 | 0.0522 | −0.0205 | 0.0109 | −0.0480 | −0.0034 | −0.163265 | |
PIK3R2 | cg11953794 | 0.2101 | −0.0753 | 0.0262 | 0.0073 | 0.2804 | 0.4185 | 0.1330 | 0.0037 | 0.0575 | 0.0218 | 0.0133 | −0.0315 | 0.0134 | −0.0659 | −0.0109 | −0.251347 |
cg04610450 | 0.1700 | −0.0442 | 0.0176 | 0.0171 | 0.2369 | 0.5647 | 0.2045 | 0.0097 | 0.0510 | 0.0219 | 0.0272 | −0.0250 | 0.0127 | −0.0600 | −0.0068 | −0.199292 | |
PRKCZ | cg02481000 | 0.1183 | −0.0434 | 0.0213 | 0.0501 | 0.1988 | 0.4175 | 0.1728 | 0.0220 | 0.0441 | 0.0218 | 0.0523 | −0.0181 | 0.0120 | −0.0530 | −0.0024 | −0.14457 |
TGFBR2 | cg04916416 | 0.1641 | 0.0412 | 0.0167 | 0.0193 | 0.1691 | −0.4793 | 0.2246 | 0.0411 | 0.0457 | 0.0228 | 0.0543 | −0.0197 | 0.0114 | −0.0514 | −0.0032 | −0.157375 |
TLR6 | cg14578677 | 0.1978 | −0.0707 | 0.0256 | 0.0095 | 0.1637 | 0.3060 | 0.1470 | 0.0460 | 0.0476 | 0.0234 | 0.0506 | −0.0216 | 0.0130 | −0.0563 | −0.0029 | −0.172535 |
TNFAIP3 | cg22014112 | 0.1467 | 0.0563 | 0.0244 | 0.0278 | 0.1868 | −0.3499 | 0.1519 | 0.0284 | 0.0457 | 0.0223 | 0.0497 | −0.0197 | 0.0131 | −0.0576 | −0.0024 | −0.157265 |
TNFRSF1B | cg05599723 | 0.1221 | −0.0465 | 0.0224 | 0.0462 | 0.1850 | 0.3790 | 0.1657 | 0.0294 | 0.0436 | 0.0221 | 0.0573 | −0.0176 | 0.0111 | −0.0496 | −0.0024 | −0.140605 |
cg15526535 | 0.1349 | 0.0389 | 0.0177 | 0.0355 | 0.1947 | −0.4959 | 0.2086 | 0.0240 | 0.0453 | 0.0221 | 0.0493 | −0.0193 | 0.0113 | −0.0496 | −0.0038 | −0.153835 | |
cg22677556 | 0.2258 | 0.0679 | 0.0226 | 0.0052 | 0.1711 | −0.3567 | 0.1656 | 0.0394 | 0.0502 | 0.0237 | 0.0424 | −0.0242 | 0.0107 | −0.0539 | −0.0084 | −0.193363 | |
TRAF5 | cg10721755 | 0.1654 | −0.0516 | 0.0208 | 0.0188 | 0.2716 | 0.5175 | 0.1686 | 0.0045 | 0.0527 | 0.0214 | 0.0198 | −0.0267 | 0.0140 | −0.0644 | −0.0070 | −0.212858 |
ZAP70 | cg08859278 | 0.1844 | 0.0475 | 0.0179 | 0.0126 | 0.2533 | −0.5756 | 0.1979 | 0.0068 | 0.0533 | 0.0219 | 0.0211 | −0.0273 | 0.0135 | −0.0627 | −0.0073 | −0.2181 |
Mediation effects that survived Bonferroni correction are presented in italics
BCL10 B cell CLL/lymphoma 10, DDR1 discoidin domain receptor tyrosine kinase 1, FLT1 Fms-related tyrosine kinase 1, IGF1R insulin-like growth factor 1 receptor, IL1R2 interleukin 1 receptor, type II, LCK lymphocyte-specific protein tyrosine kinase, LTA lymphotoxin alpha, LTBR lymphotoxin beta receptor (TNFR superfamily, member 3), MAP3K14 mitogen-activated protein kinase kinase kinase 14, MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4, NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B cell inhibitor, alpha, PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta, PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta), PRKCZ protein kinase C, zeta, TGFBR2 transforming growth factor, beta receptor II, TLR6 Toll-like receptor 6, TNFAIP3 tumor necrosis factor, alpha-induced protein 3, TNFRSF1B tumor necrosis factor receptor superfamily, member 1B, TRAF5 TNF receptor-associated factor 5, ZAP70 zeta-chain (TCR)-associated protein kinase 70 kDa, SE standard error, LLCI lower limit confidence interval, ULCI upper limit confidence interval