Table 3.
Gene | CpG site | DNA methylation | IL-2 outcome | Mediation effect | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R 2 | Storm32 | R 2 | DNA methylation | Storm32 | |||||||||||||
Effect (a) | SE | p val. | Effect (b) | SE | p val. | Effect (c') | SE | p val. | Effect (a*b) | Boot SE | Boot LLCI | Boot ULCI | Standardized Effect | ||||
DDR1 | cg11975790 | 0.1813 | 0.0527 | 0.0201 | 0.0135 | 0.1458 | 0.2919 | 0.1926 | 0.1402 | 0.0209 | 0.0238 | 0.3882 | 0.0154 | 0.0109 | 0.0001 | 0.0449 | 0.12033 |
LCK | cg05350315 | 0.1949 | 0.0711 | 0.0260 | 0.0101 | 0.1468 | 0.2279 | 0.1492 | 0.1372 | 0.0201 | 0.0240 | 0.4104 | 0.0162 | 0.0123 | 0.0001 | 0.0504 | 0.126718 |
LTA | cg21999229 | 0.2593 | 0.1120 | 0.0340 | 0.0025 | 0.1579 | 0.1881 | 0.1132 | 0.1071 | 0.0152 | 0.0249 | 0.5459 | 0.0211 | 0.0131 | 0.0015 | 0.0559 | 0.164705 |
cg14597739 | 0.2618 | 0.1198 | 0.0361 | 0.0023 | 0.2009 | 0.2206 | 0.1037 | 0.0418 | 0.0098 | 0.0243 | 0.6884 | 0.0264 | 0.0145 | 0.0061 | 0.0681 | 0.206707 | |
cg16219283 | 0.2575 | 0.1038 | 0.0316 | 0.0026 | 0.1693 | 0.2163 | 0.1208 | 0.0833 | 0.0138 | 0.0247 | 0.5799 | 0.0224 | 0.0142 | 0.0020 | 0.0620 | 0.175555 | |
cg17169196 | 0.2233 | 0.0894 | 0.0299 | 0.0055 | 0.1498 | 0.2020 | 0.1292 | 0.1284 | 0.0182 | 0.0244 | 0.4616 | 0.0181 | 0.0134 | 0.0000 | 0.0566 | 0.141177 | |
cg02402436 | 0.2261 | 0.0932 | 0.0310 | 0.0052 | 0.1701 | 0.2221 | 0.1234 | 0.0818 | 0.0156 | 0.0242 | 0.5244 | 0.0207 | 0.0113 | 0.0038 | 0.0528 | 0.161848 | |
cg14441276 | 0.2038 | 0.0741 | 0.0263 | 0.0084 | 0.1522 | 0.2338 | 0.1467 | 0.1216 | 0.0189 | 0.0241 | 0.4380 | 0.0173 | 0.0119 | 0.0004 | 0.0513 | 0.135532 | |
TGFBR2 | cg04916416 | 0.1641 | 0.0412 | 0.0167 | 0.0193 | 0.1289 | 0.3029 | 0.2346 | 0.2065 | 0.0238 | 0.0238 | 0.3259 | 0.0125 | 0.0090 | 0.0006 | 0.0370 | 0.097494 |
None of the mediation effects survived Bonferroni correction