Table 4.
Gene | CpG site | DNA methylation | IL-4 outcome | Mediation effect | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R 2 | Storm32 | R 2 | DNA methylation | Storm32 | |||||||||||||
Effect (a) | SE | p val. | Effect (b) | SE | p val. | Effect (c') | SE | p val. | Effect (a*b) | Boot SE | Boot LLCI | Boot ULCI | Standardized effect | ||||
BCL10 | cg01636910 | 0.1332 | −0.0506 | 0.0232 | 0.0367 | 0.2035 | −0.2347 | 0.1441 | 0.1139 | 0.0297 | 0.0200 | 0.1466 | 0.0119 | 0.0091 | 0.0006 | 0.0368 | 0.104041 |
IGF1R | cg13297560 | 0.1322 | 0.0388 | 0.0178 | 0.0375 | 0.2072 | 0.3125 | 0.1866 | 0.1044 | 0.0295 | 0.0199 | 0.1489 | 0.0121 | 0.0093 | 0.0004 | 0.0386 | 0.106277 |
LCK | cg17078393 | 0.2561 | 0.0659 | 0.0202 | 0.0027 | 0.2394 | 0.3308 | 0.1616 | 0.0495 | 0.0198 | 0.0211 | 0.3547 | 0.0218 | 0.0132 | 0.0037 | 0.0563 | 0.191284 |
cg05350315 | 0.1949 | 0.0711 | 0.0260 | 0.0101 | 0.2457 | 0.2648 | 0.1252 | 0.0428 | 0.0228 | 0.0202 | 0.2673 | 0.0188 | 0.0119 | 0.0029 | 0.0524 | 0.165089 | |
MAP3K14 | cg16826777 | 0.1665 | −0.0516 | 0.0207 | 0.0184 | 0.2167 | −0.2857 | 0.1597 | 0.0838 | 0.0269 | 0.0202 | 0.1931 | 0.0147 | 0.0093 | 0.0018 | 0.0396 | 0.129202 |
PIK3CD | cg07499142 | 0.1747 | 0.0599 | 0.0234 | 0.0155 | 0.2021 | 0.2300 | 0.1429 | 0.1178 | 0.0278 | 0.0205 | 0.1842 | 0.0138 | 0.0090 | 0.0003 | 0.0373 | 0.120821 |
PIK3R2 | cg11953794 | 0.2101 | −0.0753 | 0.0262 | 0.0073 | 0.2113 | −0.2185 | 0.1267 | 0.0949 | 0.0252 | 0.0208 | 0.2359 | 0.0164 | 0.0105 | 0.0001 | 0.0403 | 0.144195 |
cg04610450 | 0.1700 | −0.0442 | 0.0176 | 0.0171 | 0.2008 | −0.3036 | 0.1904 | 0.1214 | 0.0282 | 0.0204 | 0.1780 | 0.0134 | 0.0094 | 0.0003 | 0.0389 | 0.117742 | |
PRKCZ | cg02481000 | 0.1183 | −0.0434 | 0.0213 | 0.0501 | 0.2340 | −0.3056 | 0.1538 | 0.0560 | 0.0283 | 0.0194 | 0.1546 | 0.0133 | 0.0099 | 0.0007 | 0.0412 | 0.11632 |
TLR6 | cg14578677 | 0.1978 | −0.0707 | 0.0256 | 0.0095 | 0.2094 | −0.2213 | 0.1301 | 0.0992 | 0.0260 | 0.0207 | 0.2187 | 0.0156 | 0.0116 | 0.0008 | 0.0470 | 0.137144 |
TNFRSF1B | cg05599723 | 0.1221 | −0.0465 | 0.0224 | 0.0462 | 0.2060 | −0.2470 | 0.1488 | 0.1075 | 0.0301 | 0.0198 | 0.1387 | 0.0115 | 0.0086 | 0.0003 | 0.0350 | 0.100689 |
ZAP70 | cg08859278 | 0.1844 | 0.0475 | 0.0179 | 0.0126 | 0.2172 | 0.3310 | 0.1844 | 0.0828 | 0.0259 | 0.0204 | 0.2142 | 0.0157 | 0.0093 | 0.0019 | 0.0405 | 0.137839 |
None of the mediation effects survived Bonferroni correction