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. 2016 May 10;7:11460. doi: 10.1038/ncomms11460

Figure 5. Pharmacological blockade of ASIC3 eliminated SDNS-induced action potentials in wild-type Pv+ DRG neurons.

Figure 5

(a) Amiloride (200 μM), a broad-spectrum ASIC/ENaC channel blocker, blocked SDNS-induced action potentials in wild-type Pv+ DRG neurons. (b) APETx2 (1 μM), a potent and selective inhibitor of ASIC3, also blocked SDNS-induced action potentials in wild-type Pv+ DRG neurons. (c,d) In contrast, DNI still evoked action potentials in the presence of amiloride (200 μM or 1 mM) in wild-type DRG proprioceptors. (e) Similarly, DNI also generated action potentials in Asic3 knockout Pv+ DRG neurons. RMP, resting membrane potential.