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. Author manuscript; available in PMC: 2017 Apr 5.
Published in final edited form as: Structure. 2016 Mar 17;24(4):641–651. doi: 10.1016/j.str.2016.02.013

Figure 2. CH3 Interface Designs.

Figure 2

A) Cartoons of the residues at the CH3 interface. B) Design 7.8 and how its mutations destabilize the two homodimers (red dashes = collision; purple dashes = electrostatic repulsion). Design 7.4 differs from design 7.8 only in the absence of A_D399M. Design 7.7 differs from design 7.8 only in having A_K409I instead of A_K409V. C) Design 11.2. Collisions between B_E357D and a_Y349 and between B_S364Q and a_K370 are predicted to destabilize the BB homodimer; the AA homodimer was not predicted to be destabilized.