Table 2.
Cox proportional hazards model for lifestyle/comorbidity variables and breast cancer-specific mortality in a pooled cohort of US breast cancer survivors (n=9513).
| Deaths/N | Model 1 | Model 2 | Model 3 | Model 4 | ||
|---|---|---|---|---|---|---|
|
|
||||||
| Body Mass Index | ||||||
| Underweight (<18.5) | 21/ | 139 | 1.45 (0.83–2.53) | 1.41 (0.81–2.45) | ||
| Normal (18.5–24.9) | 429/ | 3889 | Reference | Reference | ||
| Overweight (25.0–29.9) | 389/ | 3154 | 1.07 (0.92–1.25) | 1.05 (0.90–1.22) | ||
| Obese I (30.0–34.9) | 192/ | 1471 | 1.10 (0.91–1.33) | 1.04 (0.86–1.27) | ||
| Obese II (≥35.0) | 100/ | 860 | 1.05 (0.83–1.32) | 0.95 (0.74–1.20) | ||
| Comorbidities | ||||||
| None | 715/ | 6037 | Reference | Reference | ||
| Diabetes | 29/ | 198 | 1.49 (0.99–2.23)* | 1.43 (0.95–2.15)* | ||
| Hypertension | 332/ | 2855 | 1.12 (0.96–1.31) | 1.11 (0.95–1.30) | ||
| Hypertension & Diabetes | 55/ | 423 | 1.34 (0.97–1.85)* | 1.32 (0.95–1.84)* | ||
| Physical Activity | ||||||
| Low (MET hrs/wk < 1.5) | 274/ | 1865 | 1.22 (1.05–1.42)** | 1.21 (1.03–1.41)** | ||
| Not-low (MET hrs/wk ≥ 1.5) | 857/ | 7648 | Reference | Reference | ||
Model 1: BMI on breast cancer-specific mortality
Model 2: Comorbidities on breast cancer-specific mortality
Model 3: Physical activity on breast cancer-specific mortality
Model 4: BMI, Comorbidities, and Physical activity on breast cancer-specific mortality
All models controlled for race/ethnicity, stage, grade, age diagnosed, estrogen receptor status, chemotherapy, pack years smoked, and current smoking.
*
P-value < 0.1
**
P-value < 0.05