Table 3.
Cox proportional hazards model for lifestyle/comorbidity variables and all-cause mortality in a pooled cohort of US breast cancer survivors (n=9513).
| Deaths/N | Model 1 | Model 2 | Model 3 | Model 4 | ||
|---|---|---|---|---|---|---|
|
|
||||||
| Body Mass Index | ||||||
| Underweight (<18.5) | 67/ | 139 | 2.48 (1.84–3.34)** | 2.32 (1.72–3.12)** | ||
| Normal (18.5–24.9) | 817/ | 3889 | Reference | Reference | ||
| Overweight (25.0–29.9) | 731/ | 3154 | 1.05 (0.94–1.17) | 1.00 (0.89–1.11) | ||
| Obese I (30.0–34.9) | 377/ | 1471 | 1.19 (1.05–1.36)** | 1.06 (0.92–1.21) | ||
| Obese II (≥35.0) | 220/ | 860 | 1.31 (1.12–1.54)** | 1.05 (0.88–1.24) | ||
| Comorbidities | ||||||
| None | 1148/ | 6037 | Reference | Reference | ||
| Diabetes | 70/ | 198 | 1.89 (1.45–2.45)** | 1.77 (1.36–2.30)** | ||
| Hypertension | 805/ | 2855 | 1.30 (1.17–1.44)** | 1.27 (1.14–1.42)** | ||
| Hypertension & Diabetes | 189/ | 423 | 2.29 (1.91–2.74)** | 2.16 (1.79–2.60)** | ||
| Physical Activity | ||||||
| Low (MET hrs/wk < 1.5) | 594/ | 1865 | 1.43 (1.29–1.59)** | 1.35 (1.22–1.51)** | ||
| Not-low (MET hrs/wk ≥ 1.5) | 1618/ | 7648 | Reference | Reference | ||
Model 1: BMI on all-cause mortality
Model 2: Comorbidities on all-cause mortality
Model 3: Physical activity on all-cause mortality
Model 4: BMI, Comorbidities, and Physical activity on all-cause mortality
All models controlled for race/ethnicity, stage, grade, age diagnosed, estrogen receptor status, chemotherapy, pack years smoked, and current smoking.
**
P-value < 0.05