Table 2.
Factors Associated With Detection of HCV Shedding Into Semen in 33 HIV-Infected Men With Recent and Chronic HCV Infection
| Characteristic | HCV Detected n = 11 | HCV not Detected n = 22 | P Value |
|---|---|---|---|
| Median age (IQR), years | 46 (34–54) | 40 (31–50) | .2 |
| HIV parameters | |||
| Median duration of HIV infection (IQR), years | 9 (4–12) | 9 (3–14) | 1.0 |
| Median CD4 count (IQR), cells/µL | 702 (469–837) | 691 (501–816) | .8 |
| Detectable HIV viremia (%) | 7 (64) | 8 (36) | .2 |
| Receiving cART (%) | 11 (100) | 21 (96) | 1.0 |
| Reactive RPR (%) | 6 (55) | 9 (41) | .4 |
| HCV status | |||
| Recent (%) | 6 (29) | 15 (71) | |
| Chronic (%) | 5 (42) | 7 (58) | .5 |
| Primary infection (%) | 9 (31) | 20 (69) | |
| Reinfection (%) | 2 (50) | 2 (50) | .6 |
| Time from HCV onset to first semen donation (IQR), median weeksa | 7 (3–11) | 8 (5–17) | .3 |
| Median ALT (IQR), U/Lb | 107 (61–523) | 138 (68–249) | .6 |
| Median blood HCV VL (IQR), log10 IU/mLb | 6.64 (6.18–7.00) | 5.64 (4.20–6.35) | .02 |
Abbreviations: ALT, alanine aminotransferase; cART, combination antiretroviral therapy; HCV, hepatitis C virus; HIV, human immunodeficiency virus; IU, international units; IQR, interquartile range; n, number; RPR, rapid plasma reagin; VL, viral load.
a In men with recent HCV only.
b Levels at baseline.