. Author manuscript; available in PMC: 2017 Mar 15.

Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 18;1015-1016:201–208. doi: 10.1016/j.jchromb.2016.02.018

Table 3.

Pharmacokinetic parameters of bupropion and metabolites in healthy volunteers (n=3; 1 white male, 1 Asian female and 1 white female) administered single 100 mg oral dose of racemic bupropion.

	t_1/2	t_max	C_max	AUC_0–∞	Cl/F
	(hr)	(hr)	(ng × mL⁻¹)	(ng × mL⁻¹ × hr)	(L × hr⁻¹)
R-bupropion	17.6±5.9	1.0	68.5±16.5	322.9±114.0	169.0±61.2
S-bupropion	13.9±9.2	1.5	11.6±2.3	56.0±26.3	1112±702
(2R,3R)-4-hydroxybupropion	23.3±1.9	2.0	276.0±157	10148±5408	-
(2S,3S)-4-hydroxybupropion	15.7±2.2	2.0	11.5±6.7	233±194	-
Erythro-dihydrobupropion A	31.7±5.4	4	8.7±3.0	433±157	-
Erythro-dihydrobupropion B	22.4±4.6	2.0	3.8±2.0	75.4±35.1	-
Threo-dihydrobupropion A	59.9±25.9	6	20.6±4.9	2038±1323	-
Threo-dihydrobupropion B	9.8±2.7	1.5	55.1±237.2	124.8±80.6	-