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The metabolism of R- and S-bupropion with human S9 fraction.
| Peak Area (counts) | ||||||
|---|---|---|---|---|---|---|
| R,R OH BUP |
S,S OH BUP |
Ery A | Ery B | Threo A |
Threo B | |
| R-BUP + S9 | 26800 | 12900 | 6440 | 3090 | 43900 | 211000 |
| S-BUP + S9 | 4370 | 41300 | 351 | 15000 | 3800 | 562000 |
|
Metabolic ratio (R- BUP/S-BUP) |
6.1 | 0.3 | 18.3 | 0.21 | 11.6 | 0.38 |
