Table 1.

Pain and ACS Rates for time on and off Hydroxyurea in the SAC cohort.^#

Type of Event	On	Off	P-value*
	Hydroxyurea	Hydroxyurea
Pain rate (events/patient year)	1.02 (2.41) §	0.56 (0.99)	0.003
ACS rate (events/patient year)	0.18 (0.71)	0.25 (0.40)	0.891

^*Wilcoxon signed rank test

^#Includes only those followed since birth and administered hydroxyurea; n=52

^§Median (IQR)

Duration of hydroxyurea therapy ranges from 0.10 to 13.92 years. The mean is 3.59 years, median is 2.50 years.