Table 5.
Final multiple variable negative binomial regression models for prospective pain and ACS events in the Sleep and Asthma Cohort Study Cohort Study when spirometry results and skin testing are included in the regression model. The minimum age of the cohort, four years, decreased the number of children with evaluable spirometry and skin testing results. Participants with complete data on spirometry and skin tests (n= 130).
| Outcome | Covariate* | Incidence Rate Ratio | 95% Conf. Interval | P** |
|---|---|---|---|---|
| Prospective ACS§ | Gender (female) | 1.54 | (0.94, 2.53) | 0.089 |
| ACS episode before age 4 | 2.56 | (1.59, 4.12) | <0.001 | |
| Wheezing caused shortness of breath | 1.78 | (1.02, 3.09) | 0.042 | |
| Wheezing after exercise | 1.31 | (0.78, 2.22) | 0.312 | |
| Two or more positive skin tests | 1.87 | (1.16, 3.00) | 0.010 | |
| FEV1/FVC <LLN | 0.86 | (0.48, 1.53) | 0.606 | |
| Bronchodilator response ≥ 12% | 1.18 | (0.66, 2.11) | 0.581 | |
| Prospective Pain§ | Age of first contact | 1.05 | (0.99, 1.12) | 0.116 |
| Hemoglobin (g/dl)# | 1.32 | (1.09, 1.60) | 0.004 | |
| Mother has asthma | 1.50 | (0.73, 3.09) | 0.273 | |
| Two or more positive skin tests | 1.14 | 0.68, 1.92) | 0.628 | |
| FEV1/FVC <LLN | 0.76 | (0.42, 1.39) | 0.377 | |
| Bronchodilator response ≥ 12% | 0.89 | (0.48, 1.66) | 0.720 |
Negative Binomial regression model with adjustment for over dispersion. Two-tailed significance values.
130 patients with non-missing data in SAC cohort with skin tests, bronchodilator response, and lower airway obstruction, defined as the forced expired volume in 1 second/forced vital capacity (FEV1/FVC) < lower limit of normal (LLN) according these equations provided by Quanjer et al.14